Expected Release: 2011 March
Welcome...
KinaseNET is a free on-line resource that is currently being developed by Kinexus Bioinformatics Corporation to foster the study
of human protein kinases to advance biomedical research in academia and industry. KinaseNET will hold comprehensive data
on 515 human protein kinases. This will include information on the nucleotide and amino acid sequences, regulation, substrate
specificity, tissue distribution and evolutionary conservation of individual protein kinases in diverse species. KinaseNET
will feature direct links to many other useful websites, and will continue to expand to become a premier portal for protein
kinase information.
Role of Protein Kinases …
Protein kinases are responsible for catalyzing the reversible phosphorylation of perhaps as many as 500,000 phosphorylation
sites in most of the 23,000 proteins encoded by the human genome. Approximately a third of the therapeutic drugs currently
in develop target protein kinases. However, more than 80% of the protein kinases remain to be investigated as targets for
therapeutics development. It has been estimated that over 400 human diseases are linked to defects in protein kiinase signalling
pathways. Kinexus is committed to facilitating the identification of protein kinases that are suitable as disease biomarkers and
drug targets.
Instructions …
KinaseNET is designed to be fast and simple to navigate. You will be able to search for a target protein kinase if you know its Uniprot ID or
its one of its common alias names. A list of possible options for protein kinases will be generated by typing at least three letters of their
name, and waiting for several seconds for a complete list to appear. Once a unique protein kinase webpage is created, you will be able to scroll
down the webpage to learn more about the kinase. The optimum web browsers for using KinaseNET will be Internet Explorer and Firefox
Also Coming Soon…
KinaseNET is the second of several planned on-line knowledgebases that will become available from Kinexus Bioinformatics Corporation as part of
our SigNET KnowledgeBank to accelerate signal transduction research. Additional knowledgebases for
human protein phosphatases, adapter proteins, and stress proteins are also currently in development.
Advertising Opportunities …
To develop and sustain this free resource, we are seeking sponsorship from foundations and
corporations. It is also possible for commercial vendors of signal transduction reagents and
services to
advertise their relevant products and services on this site. Interested parties
should contact our Sales and Marketing Department at info@kinexus.ca or call toll free in
North America 1-866-KINEXUS.
|
© 2010 Kinexus Bioinformatics Corporation |