Nomenclature
Short Name:
ADCK2
Full Name:
AarF domain containing kinase 2
Alias:
- BG832130
Classification
Type:
Protein-serine/threonine kinase
Group:
Atypical
Family:
ABC1
SubFamily:
ABC1-C
Structure
Mol. Mass (Da):
68,982
# Amino Acids:
626
# mRNA Isoforms:
1
mRNA Isoforms:
68,982 Da (626 AA; Q7Z695)
4D Structure:
NA
1D Structure:
Subfamily Alignment
Domain Distribution:
| Start | End | Domain |
|---|---|---|
| 1 | 18 | signal_peptide |
| 307 | 626 | ABC1 |
| Pkinase |
Post-translation Modifications
For detailed information on phosphorylation of this kinase go to PhosphoNET
Threonine phosphorylated:
T387.
Tyrosine phosphorylated:
Y218.
Distribution
Based on gene microarray analysis from the NCBI
Human Tissue Distribution
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
73
936
55
1020
6
76
23
56
5
60
7
51
33
430
159
533
58
742
47
648
3
40
148
35
4
54
51
52
70
908
53
1884
41
525
31
375
5
65
124
89
7
93
40
95
69
887
254
634
4
48
51
41
5
67
15
65
6
80
25
98
4
58
28
44
17
215
232
174
7
86
18
84
5
63
142
54
44
573
215
613
14
187
24
175
8
105
32
104
4
46
11
31
5
59
18
45
9
116
24
118
53
687
83
688
5
70
54
62
7
85
18
60
6
79
18
76
7
92
56
60
47
607
36
798
100
1290
66
2658
20
254
91
900
78
1000
104
741
12
161
61
228
Evolution
Species Conservation
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
100
100
100
98.7
99.5
99
98.7
99.5
95
-
-
79
-
-
-
95.4
97.1
80.5
80
86.7
-
-
-
76
74.1
82.1
74
72.2
81.2
-
-
-
-
-
-
62
55
67.7
58
-
-
57
49.8
63.4
-
-
-
-
-
-
-
-
-
41
26.7
44.9
-
38.5
55.8
-
-
-
-
-
-
30
-
-
37
-
-
38
21.5
38.5
37
For a wider analysis go to PhosphoNET Evolution in PhosphoNET
Regulation
Activation:
NA
Inhibition:
NA
Synthesis:
NA
Degradation:
NA
Protein Kinase Specificity
Matrix of observed frequency (%) of amino acids in aligned protein substrate phosphosites
Matrix Type:
Predicted from the application of the Kinexus Kinase Substrate Predictor Version 2.0 algorithm, which was trained with over 10,000 kinase-protein substrate pairs and 8,000 kinase-peptide substrate pairs.
Domain #:
1
Disease Linkage
General Disease Association:
Congenital bone malformation
Specific Diseases (Non-cancerous):
Klippel-Feil Syndrome
Comments:
Klippel-Feil Syndrome is a rare disorder characterized by the congenital fusion of any 2 of the 7 cervical (neck) vertebrae, which is caused by a failure in the normal segmentation or division of the cervical vertebrae during the early weeks of fetal development.
Gene Expression in Cancers:
The COSMIC website notes an up-regulated expression score for ADCK2 in diverse human cancers of 699, which is 1.5-fold of the average score of 462 for the human protein kinases. The down-regulated expression score of 76 for this protein kinase in human cancers was 1.3-fold of the average score of 60 for the human protein kinases.
Mutagenesis Experiments:
Insertional mutagenesis studies in mice have not yet revealed a role for this protein kinase in mouse cancer oncogenesis.
Mutation Rate in All Cancers:
Percent mutation rates per 100 amino acids length in human cancers: 0.05 % in 24726 diverse cancer specimens. This rate is only -35 % lower than the average rate of 0.075 % calculated for human protein kinases in general.
Mutation Rate in Specific Cancers:
Highest percent mutation rates per 100 amino acids length in human cancers: 0.24 % in 864 skin cancers tested; 0.24 % in 1270 large intestine cancers tested.
Frequency of Mutated Sites:
None >2 in 19643 cancer specimens
Comments:
Only 3 deletions, no insertions and 1 complex mutations are noted on the COSMIC website.