Nomenclature
Short Name:
DCAMKL3
Full Name:
Serine-threonine-protein kinase DCAMKL3
Alias:
- DCLK3
- Doublecortin-like kinase 3
- EC 2.7.11.1
- KIAA1765
Classification
Type:
Protein-serine/threonine kinase
Group:
CAMK
Family:
DCAMKL
SubFamily:
NA
Structure
Mol. Mass (Da):
73,814
# Amino Acids:
648
# mRNA Isoforms:
1
mRNA Isoforms:
73,814 Da (648 AA; Q9C098)
4D Structure:
NA
1D Structure:
Subfamily Alignment
Domain Distribution:
| Start | End | Domain |
|---|---|---|
| 356 | 613 | Pkinase |
Post-translation Modifications
For detailed information on phosphorylation of this kinase go to PhosphoNET
Serine phosphorylated:
S182, S390, S591.
Tyrosine phosphorylated:
Y382.
Distribution
Based on gene microarray analysis from the NCBI
Human Tissue Distribution
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
77
1341
9
1287
38
661
3
628
-
-
-
-
3
60
25
182
30
526
8
223
0.5
8
9
4
0.2
4
10
4
26
451
2
98
-
-
-
-
6
112
26
357
25
429
2
103
35
617
8
281
22
392
2
91
98
1709
2
1338
57
999
2
1082
3
58
7
113
15
255
6
410
52
918
2
779
17
305
20
940
31
537
30
509
73
1269
2
202
-
-
-
-
-
-
-
-
100
1750
4
561
24
419
2
225
25
440
18
313
33
582
2
645
35
605
2
26
10
172
2
129
2
37
14
32
-
-
-
-
15
266
13
728
0.2
3
12
0
28
493
26
428
3
48
22
46
Evolution
Species Conservation
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
100
100
100
29.1
44.3
99.5
75.4
76
97
-
-
79
-
-
-
46.5
57.2
77
-
-
-
72.2
79.5
76
60.1
66.7
78
-
-
-
46.9
57.7
-
42.3
48.5
56
-
-
-
31.9
45.9
-
-
-
-
-
-
-
-
-
-
-
-
42
32.7
44.1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
For a wider analysis go to PhosphoNET Evolution in PhosphoNET
Regulation
Activation:
NA
Inhibition:
NA
Synthesis:
NA
Degradation:
NA
Protein Kinase Specificity
Matrix of observed frequency (%) of amino acids in aligned protein substrate phosphosites
Matrix Type:
Predicted from the application of the Kinexus Kinase Substrate Predictor Version 2.0 algorithm, which was trained with over 10,000 kinase-protein substrate pairs and 8,000 kinase-peptide substrate pairs.
Domain #:
1
Inhibitors
For further details on these inhibitors click on the Compound Name and enter it into DrugKiNET or click on the ID's
Based on in vitro and/or in vivo phosphorylation data
| Compound Name | KD, Ki or IC50 (nM) | PubChem ID | ChEMBL ID | PubMed ID |
|---|
Disease Linkage
Gene Expression in Cancers:
The COSMIC website notes an up-regulated expression score for DCAMKL3 in diverse human cancers of 418, which is 0.9-fold of the average score of 462 for the human protein kinases. The down-regulated expression score of 0 for this protein kinase in human cancers was 100% lower than the average score of 60 for the human protein kinases.
Mutagenesis Experiments:
Insertional mutagenesis studies in mice have not yet revealed a role for this protein kinase in mouse cancer oncogenesis.
Mutation Rate in All Cancers:
Percent mutation rates per 100 amino acids length in human cancers: 0.11 % in 24991 diverse cancer specimens. This rate is a modest 1.51-fold higher than the average rate of 0.075 % calculated for human protein kinases in general.
Mutation Rate in Specific Cancers:
Highest percent mutation rates per 100 amino acids length in human cancers: 0.75 % in 864 skin cancers tested; 0.48 % in 1351 large intestine cancers tested; 0.31 % in 589 stomach cancers tested; 0.3 % in 1685 lung cancers tested; 0.2 % in 603 endometrium cancers tested.
Frequency of Mutated Sites:
Most frequent mutations with the number of reports indicated in brackets: E422K (4).
Comments:
Only 3 deletions, 1 insertion, and no complex mutations are noted on the COSMIC website.