Nomenclature
Short Name:
EPHA10
Full Name:
Ephrin type-A receptor 10
Alias:
- BI560547
Classification
Type:
Protein-tyrosine kinase
Group:
TK
Family:
Eph
SubFamily:
NA
Structure
Mol. Mass (Da):
109,628
# Amino Acids:
1008
# mRNA Isoforms:
3
mRNA Isoforms:
109,716 Da (1008 AA; Q5JZY3); 97,293 Da (892 AA; Q5JZY3-3); 32,120 Da (295 AA; Q5JZY3-2)
4D Structure:
NA
1D Structure:
Subfamily Alignment
Domain Distribution:
Post-translation Modifications
For detailed information on phosphorylation of this kinase go to PhosphoNET
N-GlcNAcylated:
N311, N486.
Serine phosphorylated:
S756.
Threonine phosphorylated:
T569.
Distribution
Based on gene microarray analysis from the NCBI
Human Tissue Distribution
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
73
1735
18
1289
0.3
7
6
7
-
-
-
-
3
71
78
105
20
480
29
346
0.3
8
27
5
1
25
33
29
5
123
5
164
0.08
2
3
2
3
65
53
75
3
73
5
96
36
864
23
452
-
-
-
-
0.1
3
3
1
7
164
5
220
0.5
12
15
6
2
44
17
104
0.1
3
3
1
3
63
39
46
15
362
82
184
6
132
5
178
2
53
5
80
-
-
-
-
0.08
2
3
1
4
95
5
130
31
727
52
803
0.1
3
3
1
0.08
2
3
0
0.08
2
3
1
8
189
28
111
26
612
12
47
100
2375
21
4435
0.08
2
36
0
30
711
78
626
25
583
48
944
Evolution
Species Conservation
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
100
100
100
40
57.4
0
47.3
65.4
-
-
-
94
-
-
43
53.2
70.7
86
-
-
-
92.2
94.7
93
52.8
70.4
89
-
-
-
53.8
70.6
-
53.4
71
63
48
64.9
-
45.1
62.5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
For a wider analysis go to PhosphoNET Evolution in PhosphoNET
Regulation
Activation:
The protein kinase domain is predicted to be catalytically inactive.
Inhibition:
NA
Synthesis:
NA
Degradation:
NA
Protein Kinase Specificity
Matrix of observed frequency (%) of amino acids in aligned protein substrate phosphosites
Matrix Type:
Predicted from the application of the Kinexus Kinase Substrate Predictor Version 2.0 algorithm, which was trained with over 10,000 kinase-protein substrate pairs and 8,000 kinase-peptide substrate pairs.
Domain #:
1
Disease Linkage
General Disease Association:
Cancer
Specific Cancer Types:
Duodenum cancer
Gene Expression in Cancers:
The COSMIC website notes an up-regulated expression score for EPHA10 in diverse human cancers of 442, which is close to the average score of 462 for the human protein kinases. The down-regulated expression score of 0 for this protein kinase in human cancers was 100% lower than the average score of 60 for the human protein kinases.
Mutagenesis Experiments:
Insertional mutagenesis studies in mice have not yet revealed a role for this protein kinase in mouse cancer oncogenesis.
Mutation Rate in All Cancers:
Percent mutation rates per 100 amino acids length in human cancers: 0.1 % in 25263 diverse cancer specimens. This rate is only 29 % higher than the average rate of 0.075 % calculated for human protein kinases in general.
Mutation Rate in Specific Cancers:
Highest percent mutation rates per 100 amino acids length in human cancers: 1.98 % in 10 peritoneum cancers tested; 0.53 % in 913 skin cancers tested; 0.39 % in 589 stomach cancers tested; 0.31 % in 1270 large intestine cancers tested; 0.26 % in 603 endometrium cancers tested; 0.2 % in 1768 lung cancers tested; 0.18 % in 548 urinary tract cancers tested.
Frequency of Mutated Sites:
Most frequent mutations with the number of reports indicated in brackets: R150H (7); A157V (4).
Comments:
Only 6 deletions, 2 insertions and no complex mutations noted on the COSMIC website.