Nomenclature
Short Name:
HSPA5
Full Name:
78 kDa glucose-regulated protein
Alias:
- BiP
- Heat shock 70kDa protein 5
- Heat-shock 70kD protein-5 (glucose-regulated protein, 78kD
- Immunoglobulin heavy chain binding protein
- MIF2
- Endoplasmic reticulum lumenal Ca
- Glucose-regulated protein
- GRP 78
- GRP78
Classification
Type:
Protein-serine/threonine kinase
Group:
Atypical
Family:
HSP
SubFamily:
NA
Specific Links
| Kinexus Products: | HSPA5 |
Structure
Mol. Mass (Da):
72,333
# Amino Acids:
654
# mRNA Isoforms:
1
mRNA Isoforms:
72,333 Da (654 AA; P11021)
4D Structure:
1D Structure:
3D Image (rendered using PV Viewer):
PDB ID
Subfamily Alignment
Domain Distribution:
| Start | End | Domain |
|---|
Kinexus Products
Click on entries below for direct links to relevant products from Kinexus for this protein kinase.
hiddentext
Post-translation Modifications
For detailed information on phosphorylation of this kinase go to PhosphoNET
Acetylated:
K96, K113, K118, K122, K123, K125, K138, K152, K154, K163, K268, K340, K352, K353, K376, K547, K579, K585, K601, K617, K619, K633, K651.
Methylated:
K581, K585, K591.
O-GalNAcylated:
T69, T203, T643.
Serine phosphorylated:
S4, S14, S86, S107, S146, S354, S365, S448, S567, S587, S588, S637.
Threonine phosphorylated:
T37, T85, T91, T139, T189, T203, T229, T366, T441, T485, T518.
Tyrosine phosphorylated:
Y39, Y65, Y127, Y160, Y466, Y570, Y635.
Ubiquitinated:
K81, K96, K113, K118, K123, K125, K138, K152, K163, K185, K213, K268, K326, K340, K352, K353, K370, K376, K447, K464, K474, K523, K547, K573, K601.
Distribution
Based on gene microarray analysis from the NCBI
Human Tissue Distribution
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
73
1494
22
877
25
516
11
180
32
645
8
220
35
717
74
578
64
1312
24
731
34
688
46
440
44
898
29
738
52
1071
26
634
72
1462
10
666
26
534
78
440
45
916
23
355
61
1253
99
686
32
655
19
203
29
599
9
270
74
1512
20
594
48
984
13
832
27
543
171
416
42
861
15
410
16
324
85
272
63
1277
84
810
34
689
19
243
24
493
21
279
35
718
17
355
49
1007
15
333
24
484
19
256
100
2041
47
857
37
753
22
185
51
1038
15
387
33
675
15
274
4
86
28
92
61
1239
18
500
35
705
20
743
79
1621
68
1572
75
1531
57
930
14
282
35
392
Evolution
Species Conservation
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
100
100
100
94
94
100
-
-
100
-
-
99
-
-
-
97.4
98
99
-
-
-
98.4
99
99
98.4
99
98.5
-
-
-
-
-
-
96.4
98.6
97
92.7
96.1
96
91.7
96
93.5
-
-
-
80.6
90.6
82.5
80.8
90.1
-
77.4
88.8
78
-
-
-
-
-
-
67.8
82.8
-
-
-
71
67.1
80.5
71
64.6
77.8
69
67
81
-
For a wider analysis go to PhosphoNET Evolution in PhosphoNET
Regulation
Activation:
NA
Inhibition:
NA
Synthesis:
NA
Degradation:
NA
Disease Linkage
General Disease Association:
Neurological, and endocrine disorders
Specific Diseases (Non-cancerous):
Spinocerebellar ataxia Type 17 (HDL4); Wolfram syndrome (WFS)
Comments:
Spinocerebellar Ataxia Type 17 (HDL4) is rare, and is related to Parkinson’s, involves the retinoblastoma regulation, and the Parkinson disease pathways. HDL4 typically affects the eye. Wolfram Syndrome (WFS) is a rare disease characterized by high blood pressure induced by lack of insulin, and progresses to blindness after optic atrophy (loss of nerves leading from the eye to the brain). WFS can affect the eye, brain, and the lung. Borna Disease results from a viral infection, it affects the brain, and is characterized by mood, behaviour, cognitive, and neurological changes, along with impaired ability to move. In vitro methylation by METTL21A is inhibited with a K585R mutation in HSPA5.
Gene Expression in Cancers:
The COSMIC website notes an up-regulated expression score for HSPA5 in diverse human cancers of 436, which is close to the average score of 462 for the human protein kinases. The down-regulated expression score of 15 for this protein kinase in human cancers was 0.3-fold of the average score of 60 for the human protein kinases.
Mutagenesis Experiments:
Insertional mutagenesis studies in mice support a role for this protein kinase in mouse cancer oncogenesis.
Mutation Rate in All Cancers:
Percent mutation rates per 100 amino acids length in human cancers: 0.04 % in 24615 diverse cancer specimens. This rate is -41 % lower than the average rate of 0.075 % calculated for human protein kinases in general.
Mutation Rate in Specific Cancers:
Highest percent mutation rates per 100 amino acids length in human cancers: 0.19 % in 1063 large intestine cancers tested.
Frequency of Mutated Sites:
None > 3 in 19,898 cancer specimens
Comments:
No deletions, insertions or complex mutations are noted on the COSMIC website.