Nomenclature
Short Name:
G11
Full Name:
Protein kinase G11
Alias:
- Serine/threonine-protein kinase 19
- STK19
- RP1
Classification
Type:
Protein-serine/threonine kinase
Group:
Atypical
Family:
G11
SubFamily:
NA
Structure
Mol. Mass (Da):
40,916
# Amino Acids:
368
# mRNA Isoforms:
4
mRNA Isoforms:
40,916 Da (368 AA; P49842); 40,495 Da (364 AA; P49842-2); 28,885 Da (258 AA; P49842-3); 28,465 Da (254 AA; P49842-4)
4D Structure:
The N-terminus interacts with BAG1
1D Structure:
Subfamily Alignment
Domain Distribution:
| Start | End | Domain |
|---|
Distribution
Based on gene microarray analysis from the NCBI
Human Tissue Distribution
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
100
1176
38
1124
64
748
13
380
8
95
16
98
33
383
117
621
76
896
31
675
8
93
88
103
19
220
38
497
69
813
44
1420
47
552
14
327
15
181
110
201
17
195
34
161
73
861
183
695
13
154
38
193
18
215
9
131
18
209
28
213
34
396
20
342
19
225
126
111
11
129
22
113
7
87
116
79
56
656
134
593
13
156
26
167
20
231
30
213
12
140
18
134
19
224
22
265
16
194
26
202
65
759
73
868
11
125
38
151
12
146
22
120
13
156
22
137
26
308
42
258
73
863
24
768
63
740
41
847
17
203
84
491
78
916
78
757
31
370
48
574
Evolution
Species Conservation
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
100
100
100
98.3
98.3
99.5
-
-
95
-
-
87
-
-
86
64.6
67.1
91
-
-
-
60.3
63.8
86
-
-
85
-
-
-
-
-
-
-
-
-
-
-
49
37.5
51.9
55
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
20.6
37.2
-
-
-
-
-
-
34
21.4
39.4
35.5
-
-
-
-
-
-
For a wider analysis go to PhosphoNET Evolution in PhosphoNET
Regulation
Activation:
NA
Inhibition:
NA
Synthesis:
NA
Degradation:
NA
Disease Linkage
General Disease Association:
Endocrine disorders
Specific Diseases (Non-cancerous):
21-Hydroxylase deficiency
Mutagenesis Experiments:
Insertional mutagenesis studies in mice have not yet revealed a role for this protein kinase in mouse cancer oncogenesis. At amino acid residues 300, 315, and 317, mutations from K to P lead to partial or complete loss of activity.
Mutation Rate in All Cancers:
Percent mutation rates per 100 amino acids length in human cancers: 0.07 % in 24433 diverse cancer specimens. This rate is only -7 % lower and is very similar to the average rate of 0.075 % calculated for human protein kinases in general.
Mutation Rate in Specific Cancers:
Highest percent mutation rates per 100 amino acids length in human cancers: 0.69 % in 864 skin cancers tested; 0.03 % in 1608 lung cancers tested.
Frequency of Mutated Sites:
Most frequent mutations with the number of reports indicated in brackets: D89N (16).
Comments:
Only 8 insertions (six at N20fs*16 and two at A19fs*17) and no deletions or complex mutations are noted on the COSMIC website.