• KinATLAS
  • TranscriptoNET
  • PhosphoNET
  • OncoNET
  • KinaseNET
  • DrugKiNET
  • DrugProNET
  • KiNET-AM
  • Kinetica Online

Updated November 2019

Home | Kinexus | Contact | Credits

Nomenclature

Short Name:
PCTAIRE2
Full Name:
Serine-threonine-protein kinase PCTAIRE-2
Alias:
  • CDK17
  • Serine/threonine-protein kinase PCTAIRE-2
  • EC 2.7.11.22
  • KPT2
  • PCTAIRE protein kinase 2
  • PCTAIRE-motif protein kinase 2
  • PCTK2

Classification

Type:
Protein-serine/threonine kinase
Group:
CMGC
Family:
CDK
SubFamily:
TAIRE
 
 

Specific Links

Entrez-Gene Entry: 5128
Entrez-Protein Entry: NP_002586
GeneCards Entry: EC.2.7.11.22
KinBASE Entry: PCTAIRE2
OMIM Entry: 603440
Pfam Entry: Q00537
PhosphoNET Entry: Q00537
Phosphosite Plus Entry: 735
ScanSite Entry: Q00537
UCSD-Nature Entry: A001738
UniProt Entry: Q00537
Kinexus Products: PCTAIRE2
Cell division protein kinase 17; Protein-serine kinase PCTAIRE-2 pan-specific antibody AB-NK285-1
Cell division protein kinase 17; Protein-serine kinase PCTAIRE-2 S180 phosphosite-specific antibody AB-PK756
Cell division protein kinase 17 / Protein-serine kinase PCTAIRE-2 (G14-E32, human) peptide - Powder PE-01BEJ85

General Links

ClustalW2
GPS-Cuckoo
Human Protein Atlas
Kinase.com
Kinase Research
Kinasource
Kinomer
Netphorest
NetworKIN
Phosida
PhosphoElm
Protein Blast
ScanSite
String

Structure

Mol. Mass (Da):
59,582
# Amino Acids:
523
# mRNA Isoforms:
2
mRNA Isoforms:
59,582 Da (523 AA; Q00537); 59,531 Da (523 AA; Q00537-2)
4D Structure:
Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7
1D Structure:
Retrieve Gene Sequence
Retrieve Full Protein Sequence
Retrieve Catalytic Domain Sequence
 
Subfamily Alignment
subfamily domain
 
Domain Distribution:
Start End Domain
192 473 Pkinase
 

Kinexus Products

Click on entries below for direct links to relevant products from Kinexus for this protein kinase.
hiddentext
○ Cell division protein kinase 17; Protein-serine kinase PCTAIRE-2 pan-specific antibody AB-NK285-1
○ Cell division protein kinase 17; Protein-serine kinase PCTAIRE-2 S180 phosphosite-specific antibody AB-PK756
○ Cell division protein kinase 17 / Protein-serine kinase PCTAIRE-2 (G14-E32, human) peptide - Powder PE-01BEJ85
 

Post-translation Modifications

For detailed information on phosphorylation of this kinase go to PhosphoNET
Acetylated:
K469.
Methylated:
K328.
Serine phosphorylated:

S9, S64, S75, S80, S92, S105, S122, S137, S146, S165, S176, S180, S182+, S346+, S444, S491, S520.
Threonine phosphorylated:

T11, T124, T202, T205.
Tyrosine phosphorylated:

Y203-, Y207.
Ubiquitinated:
K160, K194, K197, K221, K328, K452, K493.
 

Distribution

Based on gene microarray analysis from the NCBI
Human Tissue Distribution
% Max Expression:

Mean Expression:

Number of Samples:

Standard Deviation:
% Max Expression:

Mean Expression:

Number of Samples:

Standard Deviation:
  • adipose
    100

    948

    29

    1115

  • adrenal
    5

    46

    16

    43

  • bladder
    13

    127

    2

    104

  • brain
    69

    652

    91

    698

  • breast
    87

    822

    24

    732

  • cervix
    12

    118

    82

    143

  • colon
    24

    228

    35

    295

  • heart
    43

    403

    38

    519

  • intestine
    44

    417

    17

    374

  • kidney
    7

    63

    89

    72

  • liver
    8

    80

    26

    125

  • lung
    66

    622

    188

    679

  • lymphnode
    9

    87

    24

    63

  • ovary
    5

    48

    15

    51

  • pancreas
    7

    67

    20

    88

  • pituitary
    7

    70

    16

    66

  • prostate
    8

    78

    272

    100

  • salivarygland
    4

    34

    13

    27

  • skeletalmuscle"
    7

    64

    83

    51

  • skin
    66

    621

    109

    706

  • spinalcord
    21

    197

    19

    324

  • spleen
    20

    185

    22

    301

  • stomach
    3

    27

    12

    39

  • testis
    8

    77

    13

    73

  • thymus
    20

    187

    19

    352

  • thyroid
    63

    594

    52

    674

  • tonsil
    8

    73

    27

    54

  • trachea
    5

    49

    13

    41

  • uterus
    8

    80

    13

    95

  • reticulocytes"
    6

    56

    28

    39

  • t-lymphocytes
    59

    560

    24

    398

  • b-lymphocytes
    72

    684

    30

    640

  • neutrophils
    9

    89

    105

    246

  • macrophages
    93

    881

    57

    776

  • sperm
    15

    145

    35

    138

 

Evolution

Species Conservation
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
  • tableheader
    100

    100

    100
  • tableheader
    93.6

    93.8

    100
  • tableheader
    67.3

    80.1

    100
  • tableheader
    -

    -

    99
  • tableheader
    -

    -

    -
  • tableheader
    94.6

    95.1

    98
  • tableheader
    -

    -

    -
  • tableheader
    98.6

    99.8

    99
  • tableheader
    96.3

    97.7

    98.5
  • tableheader
    -

    -

    -
  • tableheader
    98.4

    99.4

    -
  • tableheader
    95.7

    97.1

    98
  • tableheader
    43.4

    56.9

    92.5
  • tableheader
    38.2

    53.9

    92
  • tableheader
    -

    -

    -
  • tableheader
    -

    -

    -
  • tableheader
    -

    -

    -
  • tableheader
    -

    -

    57
  • tableheader
    -

    -

    -
  • tableheader
    -

    -

    -
  • tableheader
    31.5

    44.5

    -
  • tableheader
    -

    -

    -
  • tableheader
    31.5

    44.1

    -
  • tableheader
    -

    -

    -
  • tableheader
    -

    -

    -
For a wider analysis go to PhosphoNET Evolution in PhosphoNET
 

Binding Proteins

Examples of known interacting proteins
hiddentext
No. Name – UniProt ID
1 TDRD7 - Q8NHU6
2 TGFBR1 - P36897
3 YWHAG - P61981
 

Regulation

Activation:
NA
Inhibition:
NA
Synthesis:
NA
Degradation:
NA
 

Protein Kinase Specificity

Matrix of observed frequency (%) of amino acids in aligned protein substrate phosphosites

Kinections GIF
Matrix Type:
Predicted from the application of the Kinexus Kinase Substrate Predictor Version 2.0 algorithm, which was trained with over 10,000 kinase-protein substrate pairs and 8,000 kinase-peptide substrate pairs.
Domain #:
1
 

Inhibitors

For further details on these inhibitors click on the Compound Name and enter it into DrugKiNET or click on the ID's
Based on in vitro and/or in vivo phosphorylation data
Compound Name KD, Ki or IC50 (nM) PubChem ID ChEMBL ID PubMed ID
R547 Kd = 860 pM 6918852 22037378
AT7519 Kd = 950 pM 11338033 22037378
AC1NS7CD Kd = 13 nM 5329665 295136 22037378
SNS032 Kd = 13 nM 3025986 296468 18183025
AST-487 Kd = 15 nM 11409972 574738 18183025
CHEMBL1082152 Kd = 69 nM 11560568 1082152 20138512
Nintedanib Kd = 93 nM 9809715 502835 22037378
Staurosporine Kd = 96 nM 5279 18183025
Foretinib Kd = 170 nM 42642645 1230609 22037378
JNJ-7706621 Kd = 290 nM 5330790 191003 18183025
TG101348 Kd = 350 nM 16722836 1287853 22037378
Alvocidib Kd = 480 nM 9910986 428690 18183025
Lestaurtinib Kd = 720 nM 126565 22037378
NVP-TAE684 Kd = 810 nM 16038120 509032 22037378
PHA-665752 Kd = 880 nM 10461815 450786 22037378
WZ3146 Kd > 1 µM 44607360 20033049
WZ4002 Kd > 1 µM 44607530 20033049
Sunitinib Kd = 1.2 µM 5329102 535 18183025
Sorafenib Kd = 1.6 µM 216239 1336 18183025
A674563 Kd = 1.9 µM 11314340 379218 22037378
KW2449 Kd = 1.9 µM 11427553 1908397 22037378
Dovitinib Kd = 3 µM 57336746 18183025
 

Disease Linkage

Gene Expression in Cancers:

TranscriptoNET (www.transcriptonet.ca) analysis with mRNA expression data retrieved from the National Center for Biotechnology Information's Gene Expression Omnibus (GEO) database, which was normalized against 60 abundantly and commonly found proteins, indicated altered expression for this protein kinase as shown here as the percent change from normal tissue controls (%CFC) as supported with the Student T-test in the following types of human cancers: Ovary adenocarcinomas (%CFC= -49, p<0.08); and Prostate cancer - primary (%CFC= +166, p<0.0001) The COSMIC website notes an up-regulated expression score for PCTAIRE2 in diverse human cancers of 369, which is 0.8-fold of the average score of 462 for the human protein kinases. The down-regulated expression score of 147 for this protein kinase in human cancers was 2.5-fold of the average score of 60 for the human protein kinases.
Mutagenesis Experiments:

Insertional mutagenesis studies in mice support a role for this protein kinase in mouse cancer oncogenesis.
Mutation Rate in All Cancers:

Percent mutation rates per 100 amino acids length in human cancers: 0.08 % in 24939 diverse cancer specimens. This rate is only 12 % higher than the average rate of 0.075 % calculated for human protein kinases in general.
Mutation Rate in Specific Cancers:

Highest percent mutation rates per 100 amino acids length in human cancers: 0.54 % in 603 endometrium cancers tested; 0.44 % in 1270 large intestine cancers tested; 0.21 % in 273 cervix cancers tested; 0.2 % in 864 skin cancers tested; 0.16 % in 589 stomach cancers tested; 0.15 % in 1822 lung cancers tested; 0.11 % in 833 ovary cancers tested; 0.08 % in 710 oesophagus cancers tested; 0.08 % in 238 bone cancers tested; 0.07 % in 881 prostate cancers tested; 0.07 % in 1316 breast cancers tested; 0.06 % in 1512 liver cancers tested; 0.04 % in 2082 central nervous system cancers tested; 0.04 % in 1276 kidney cancers tested.
Frequency of Mutated Sites:

Most frequent mutations with the number of reports indicated in brackets: R312G (4) R310S (3).
Comments:
Only 1 deletion and 1 insertion, and no complex mutations are noted on the COSMIC website.
 
COSMIC Entry:
CDK17
OMIM Entry:
603440
  • Home
  • Top of Page
Copyright 2019 Kinexus BioInformatics Corporation