Nomenclature
Short Name:
PSKH2
Full Name:
Serine/threonine-protein kinase H2
Alias:
- PSK-H2
Classification
Type:
Protein-serine/threonine kinase
Group:
CAMK
Family:
PSK
SubFamily:
NA
Structure
Mol. Mass (Da):
43,027
# Amino Acids:
385
# mRNA Isoforms:
1
mRNA Isoforms:
43,027 Da (385 AA; Q96QS6)
4D Structure:
NA
1D Structure:
Subfamily Alignment
Domain Distribution:
| Start | End | Domain |
|---|---|---|
| 63 | 320 | Pkinase |
Post-translation Modifications
For detailed information on phosphorylation of this kinase go to PhosphoNET
Myristoylated:
G2 (predicted).
Serine phosphorylated:
S356, S359, S362.
Threonine phosphorylated:
T84, T85.
Tyrosine phosphorylated:
Y63.
Distribution
Based on gene microarray analysis from the NCBI
Human Tissue Distribution
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
15
1299
9
1513
0.04
3
4
1
0.02
2
2
2
0.4
35
28
20
4
311
10
214
0.02
2
9
2
0.08
7
13
6
0.05
4
4
1
0.02
2
3
1
0.04
3
4
1
0.1
12
4
13
8
655
11
624
0.05
4
1
0
0.02
2
3
1
0.07
6
3
3
0.3
26
5
5
0.07
6
8
5
0.06
5
5
5
0.05
4
5
2
4
375
26
183
0.05
4
5
3
0.05
4
4
2
0.2
19
1
0
0.02
2
5
1
0.05
4
5
3
7
547
20
580
0.06
5
4
5
0.05
4
5
5
0.06
5
4
5
-
-
-
-
6
496
12
30
100
8394
11
8677
0.02
2
12
0
8
700
26
600
2
127
22
120
Evolution
Species Conservation
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
100
100
100
97.4
98.6
97
95
97.1
96
-
-
-
-
-
-
82.8
89.8
82.5
-
-
-
58.9
73.1
-
38.1
55.5
-
-
-
-
62
74.2
-
60.9
74
-
35
54.8
68
58.5
73.4
-
-
-
-
-
-
-
38.9
59.7
-
37.3
59.5
-
39.4
52.5
-
-
-
-
-
-
-
-
-
-
27.4
39.7
35
-
-
-
-
-
-
For a wider analysis go to PhosphoNET Evolution in PhosphoNET
Regulation
Activation:
NA
Inhibition:
NA
Synthesis:
NA
Degradation:
NA
Protein Kinase Specificity
Matrix of observed frequency (%) of amino acids in aligned protein substrate phosphosites
Matrix Type:
Predicted from the application of the Kinexus Kinase Substrate Predictor Version 2.0 algorithm, which was trained with over 10,000 kinase-protein substrate pairs and 8,000 kinase-peptide substrate pairs.
Domain #:
1
Disease Linkage
Gene Expression in Cancers:
The COSMIC website notes an up-regulated expression score for PSKH2 in diverse human cancers of 295, which is 0.6-fold of the average score of 462 for the human protein kinases. The down-regulated expression score of 0 for this protein kinase in human cancers was 100% lower than the average score of 60 for the human protein kinases.
Mutagenesis Experiments:
Insertional mutagenesis studies in mice have not yet revealed a role for this protein kinase in mouse cancer oncogenesis.
Mutation Rate in All Cancers:
Percent mutation rates per 100 amino acids length in human cancers: 0.13 % in 24777 diverse cancer specimens. This rate is 1.8-fold higher than the average rate of 0.075 % calculated for human protein kinases in general.
Mutation Rate in Specific Cancers:
Highest percent mutation rates per 100 amino acids length in human cancers: 0.81 % in 864 skin cancers tested; 0.47 % in 1270 large intestine cancers tested; 0.45 % in 1685 lung cancers tested; 0.35 % in 589 stomach cancers tested; 0.2 % in 1276 kidney cancers tested; 0.17 % in 603 endometrium cancers tested; 0.14 % in 548 urinary tract cancers tested; 0.11 % in 238 bone cancers tested; 0.1 % in 273 cervix cancers tested; 0.07 % in 710 oesophagus cancers tested; 0.07 % in 1512 liver cancers tested; 0.06 % in 942 upper aerodigestive tract cancers tested; 0.06 % in 1316 breast cancers tested; 0.05 % in 558 thyroid cancers tested; 0.04 % in 1459 pancreas cancers tested; 0.03 % in 881 prostate cancers tested; 0.03 % in 833 ovary cancers tested; 0.01 % in 2082 central nervous system cancers tested; 0.01 % in 2009 haematopoietic and lymphoid cancers tested.
Frequency of Mutated Sites:
Most frequent mutations with the number of reports indicated in brackets: G312D (9).
Comments:
No deletions, insertions or complex mutations are noted on the COSMIC website.