Nomenclature
Short Name:
GUK1
Full Name:
Guanylate kinase
Alias:
- EC 2.7.4.8
- GMK
- GMP kinase
- Guanylate kinase 1
- KGUA
Classification
Type:
Protein-serine/threonine kinase
Group:
Atypical
Family:
SubFamily:
NA
Specific Links
| Kinexus Products: | GUK1 |
Structure
Mol. Mass (Da):
21726
# Amino Acids:
197
# mRNA Isoforms:
3
mRNA Isoforms:
26,596 Da (241 AA; Q16774-3); 23,782 Da (218 AA; Q16774-2); 21,726 Da (197 AA; Q16774)
4D Structure:
1D Structure:
3D Image (rendered using PV Viewer):
PDB ID
Subfamily Alignment
Domain Distribution:
| Start | End | Domain |
|---|
Kinexus Products
Click on entries below for direct links to relevant products from Kinexus for this protein kinase.
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Post-translation Modifications
For detailed information on phosphorylation of this kinase go to PhosphoNET
Serine phosphorylated:
S158, S159, S173.
Tyrosine phosphorylated:
Y53, Y54, Y178.
Ubiquitinated:
K51, K147.
Distribution
Based on gene microarray analysis from the NCBI
Human Tissue Distribution
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
13
1103
29
974
3
234
16
184
3
235
8
193
25
2062
198
4817
9
736
28
797
3
218
81
236
6
500
35
658
9
781
40
738
8
664
17
683
4
367
115
301
26
2142
114
4758
13
1073
192
1327
2
142
30
123
2
193
15
216
4
311
25
289
4
310
16
303
2
205
204
190
4
294
17
295
16
1324
226
3904
8
693
114
724
5
384
23
413
4
361
27
479
9
704
18
603
26
2103
130
5274
4
309
23
360
9
742
54
698
2
173
33
140
3
278
18
212
3
257
17
193
100
8231
42
6321
13
1093
24
935
21
1767
36
2956
11
866
71
893
12
952
57
682
6
513
35
706
Evolution
Species Conservation
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
100
100
100
38.1
40.4
99
98.4
98.9
99
-
-
91
-
-
-
88.8
92.9
89
-
-
-
87.8
92.9
88
78
84.4
87
-
-
-
-
-
-
73.2
87.3
74
68.1
82.3
-
71.8
84.9
-
-
-
-
47.6
60.5
56
54.3
73
-
50
63.4
55
-
-
-
-
-
-
-
-
-
-
-
49
-
-
48
49.7
68.5
52
-
-
48
For a wider analysis go to PhosphoNET Evolution in PhosphoNET
Regulation
Activation:
NA
Inhibition:
NA
Synthesis:
NA
Degradation:
NA
Disease Linkage
General Disease Association:
Bone disorders
Specific Diseases (Non-cancerous):
Ankylosis
Comments:
Ankylosis is characterized by either partial or full stiffness of a joint caused by inflammation of tissues in the joint, or of tissues surrounding it. Ankylosis has been noted to have an effect on bone, skin, and brain tissues.
Gene Expression in Cancers:
TranscriptoNET (www.transcriptonet.ca) analysis with mRNA expression data retrieved from the National Center for Biotechnology Information's Gene Expression Omnibus (GEO) database, which was normalized against 60 abundantly and commonly found proteins, indicated altered expression for this protein kinase as shown here as the percent change from normal tissue controls (%CFC) as supported with the Student T-test in the following types of human cancers: Bladder carcinomas (%CFC= +88, p<0.041); Breast epithelial cell carcinomas (%CFC= +98, p<0.032); Cervical cancer stage 2A (%CFC= -56, p<0.076); Classical Hodgkin lymphomas (%CFC= +295, p<0.01); Clear cell renal cell carcinomas (cRCC) (%CFC= +50, p<0.028); Clear cell renal cell carcinomas (cRCC) stage I (%CFC= +340, p<0.0001); Large B-cell lymphomas (%CFC= +484, p<0.0007); Ovary adenocarcinomas (%CFC= +53, p<0.023); and Skin melanomas - malignant (%CFC= +233, p<0.0001). The COSMIC website notes an up-regulated expression score for GUK1 in diverse human cancers of 469, which is close to the average score of 462 for the human protein kinases. The down-regulated expression score of 39 for this protein kinase in human cancers was 0.7-fold of the average score of 60 for the human protein kinases.
Mutagenesis Experiments:
Insertional mutagenesis studies in mice have not yet revealed a role for this protein kinase in mouse cancer oncogenesis.
Mutation Rate in All Cancers:
Percent mutation rates per 100 amino acids length in human cancers: 0.08 % in 24548 diverse cancer specimens. This rate is very similar (+ 2% higher) to the average rate of 0.075 % calculated for human protein kinases in general.
Mutation Rate in Specific Cancers:
Highest percent mutation rates per 100 amino acids length in human cancers: 0.59 % in 603 endometrium cancers tested; 0.46 % in 555 stomach cancers tested; 0.24 % in 864 skin cancers tested; 0.16 % in 1608 lung cancers tested; 0.16 % in 1240 large intestine cancers tested; 0.1 % in 1512 liver cancers tested.
Frequency of Mutated Sites:
None > 3 in 19,804 cancer specimens
Comments:
No deletions, insertions or complex mutations are noted on the COSMIC website.