Nomenclature
Short Name:
TAF1L
Full Name:
Transcription initiation factor TFIID 210 kDa subunit
Alias:
- Transcription initiation factor TFIID 210 kDa subunit
Classification
Type:
Protein-serine/threonine kinase
Group:
Atypical
Family:
TAF1
SubFamily:
NA
Structure
Mol. Mass (Da):
207,302
# Amino Acids:
1826
# mRNA Isoforms:
1
mRNA Isoforms:
207,302 Da (1826 AA; Q8IZX4)
4D Structure:
Can bind directly to TATA-box binding protein (TBP).
1D Structure:
Subfamily Alignment
Domain Distribution:
| Start | End | Domain |
|---|---|---|
| 1231 | 1264 | Coiled-coil |
| 1416 | 1486 | BROMO |
| 1539 | 1609 | BROMO |
Post-translation Modifications
For detailed information on phosphorylation of this kinase go to PhosphoNET
Acetylated:
K724, K1263, K1366, K1373.
Serine phosphorylated:
S306, S543, S1174, S1359, S1410, S1583, S1652.
Threonine phosphorylated:
T564, T874, T1173, T1398, T1403.
Tyrosine phosphorylated:
Y1385, Y1560, Y1581, Y1669.
Ubiquitinated:
K720, K724.
Distribution
Based on gene microarray analysis from the NCBI
Human Tissue Distribution
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
100
2980
6
1597
0.3
8
7
3
-
-
-
-
0.8
24
29
15
12
356
13
335
0.4
11
9
9
0.2
7
16
3
0.2
6
6
3
0.2
6
6
2
0.2
7
6
2
0.1
4
6
2
23
687
12
708
-
-
-
-
0.5
15
6
5
0.1
4
6
3
0.5
16
5
9
0.5
14
10
12
0.1
3
6
2
0.1
4
6
2
15
456
29
284
0.2
5
6
2
0.3
10
6
2
-
-
-
-
0.4
12
6
3
0.3
8
6
2
16
463
22
535
0.3
8
6
2
0.2
6
6
4
0.2
7
6
4
-
-
-
-
44
1319
12
75
23
678
11
2131
0.2
7
12
1
22
666
26
570
4
121
22
73
Evolution
Species Conservation
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
100
100
100
0
0
98
-
-
95
-
-
-
-
-
-
86.5
90.6
-
-
-
-
84.8
89.7
-
85.3
89.9
-
-
-
-
30.3
36.4
-
-
-
-
-
-
-
71
78.8
-
-
-
-
43.4
58.6
-
45.9
59.5
-
30
49.4
-
49.2
63.8
-
-
-
-
-
-
-
-
-
-
20
38.2
-
-
-
26
-
-
-
For a wider analysis go to PhosphoNET Evolution in PhosphoNET
Binding Proteins
Examples of known interacting proteins
hiddentext
| No. | Name – UniProt ID |
|---|---|
| 1 | TAF8 - Q7Z7C8 |
| 2 | TAF6 - P49848 |
| 3 | TAF5 - Q15542 |
| 4 | TAF11 - Q15544 |
| 5 | TAF12 - Q16514 |
| 6 | TAF9 - Q16594 |
| 7 | TAF7 - Q15545 |
| 8 | TAF4 - O00268 |
| 9 | TBP - P20226 |
| 10 | RB1 - P06400 |
| 11 | CCND1 - P24385 |
| 12 | CSNK2A1 - P68400 |
| 13 | ASF1A - Q9Y294 |
| 14 | MSX1 - P28360 |
| 15 | FOS - P01100 |
Regulation
Activation:
NA
Inhibition:
NA
Synthesis:
NA
Degradation:
NA
Disease Linkage
Gene Expression in Cancers:
The COSMIC website notes an up-regulated expression score for TAF1L in diverse human cancers of 342, which is 0.7-fold of the average score of 462 for the human protein kinases. The down-regulated expression score of 17 for this protein kinase in human cancers was 0.3-fold of the average score of 60 for the human protein kinases.
Mutagenesis Experiments:
Insertional mutagenesis studies in mice have not yet revealed a role for this protein kinase in mouse cancer oncogenesis.
Mutation Rate in All Cancers:
Percent mutation rates per 100 amino acids length in human cancers: 0.12 % in 24909 diverse cancer specimens. This rate is 1.64-fold higher than the average rate of 0.075 % calculated for human protein kinases in general.
Mutation Rate in Specific Cancers:
Highest percent mutation rates per 100 amino acids length in human cancers: 0.55 % in 864 skin cancers tested; 0.51 % in 1346 large intestine cancers tested; 0.35 % in 1684 lung cancers tested; 0.29 % in 603 endometrium cancers tested; 0.24 % in 589 stomach cancers tested; 0.18 % in 273 cervix cancers tested; 0.1 % in 710 oesophagus cancers tested; 0.1 % in 1512 liver cancers tested; 0.1 % in 1372 breast cancers tested; 0.08 % in 65 Meninges cancers tested; 0.08 % in 548 urinary tract cancers tested; 0.07 % in 1276 kidney cancers tested; 0.06 % in 881 prostate cancers tested; 0.06 % in 2082 central nervous system cancers tested; 0.06 % in 1459 pancreas cancers tested; 0.05 % in 833 ovary cancers tested; 0.04 % in 127 biliary tract cancers tested.
Frequency of Mutated Sites:
Most frequent mutations with the number of reports indicated in brackets: R783C (6); R588Q (5); P553S (4); R685C (3); R636H (3); R888C (3).
Comments:
Over 20 deletion mutations (11 at K665fs*4), 4 insertion mutations (2 at A666fs*38), and 6 complex mutations are noted on the COSMIC website.