Nomenclature
Short Name:
RSKL2
Full Name:
Ribosomal protein S6 kinase-like 1
Alias:
- RPS6KL1
- MGC11287
Classification
Type:
Protein-serine/threonine kinase
Group:
AGC
Family:
RSKL
SubFamily:
NA
Structure
Mol. Mass (Da):
60,036
# Amino Acids:
549
# mRNA Isoforms:
3
mRNA Isoforms:
60,036 Da (549 AA; Q9Y6S9); 59,167 Da (541 AA; Q9Y6S9-2); 28,380 Da (255 AA; Q9Y6S9-4)
4D Structure:
NA
1D Structure:
Subfamily Alignment
Domain Distribution:
Post-translation Modifications
For detailed information on phosphorylation of this kinase go to PhosphoNET
Serine phosphorylated:
S369, S383.
Threonine phosphorylated:
T381.
Distribution
Based on gene microarray analysis from the NCBI
Human Tissue Distribution
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
40
1193
12
1438
0.9
28
7
24
2
47
9
32
6
171
42
339
16
469
16
496
0.5
15
9
9
0.7
21
16
16
3
98
19
182
0.6
19
6
17
3
79
43
75
2
61
19
57
10
309
25
483
2
74
9
56
0.4
11
6
9
2
68
10
101
0.1
4
5
2
5
157
84
96
4
110
15
152
5
136
47
96
11
321
34
224
4
108
19
220
2
67
19
107
2
58
9
53
1.2
36
15
48
2
53
19
71
13
386
31
536
1
29
15
28
2
73
15
70
1.3
39
15
32
22
671
14
221
30
889
12
56
100
2999
17
2608
6
187
43
474
21
639
26
549
9
257
22
358
Evolution
Species Conservation
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
100
100
100
93.2
93.4
99
90.7
91.9
96.5
-
-
87
-
-
-
74
77.3
82
-
-
-
78.6
86.6
79
20.5
34.1
80
-
-
-
25.1
35.6
-
46.2
56
-
-
-
55.5
-
41.4
61
-
-
-
21
38
-
20.9
40.6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
For a wider analysis go to PhosphoNET Evolution in PhosphoNET
Regulation
Activation:
NA
Inhibition:
NA
Synthesis:
NA
Degradation:
NA
Disease Linkage
Gene Expression in Cancers:
The COSMIC website notes an up-regulated expression score for RSKL2 in diverse human cancers of 492, which is close to the average score of 462 for the human protein kinases. The down-regulated expression score of 4 for this protein kinase in human cancers was 0.1-fold of the average score of 60 for the human protein kinases.
Mutagenesis Experiments:
Insertional mutagenesis studies in mice have not yet revealed a role for this protein kinase in mouse cancer oncogenesis.
Mutation Rate in All Cancers:
Percent mutation rates per 100 amino acids length in human cancers: 0.07 % in 24751 diverse cancer specimens. This rate is only -10 % lower and is very similar to the average rate of 0.075 % calculated for human protein kinases in general.
Mutation Rate in Specific Cancers:
Highest percent mutation rates per 100 amino acids length in human cancers: 0.34 % in 1270 large intestine cancers tested; 0.3 % in 864 skin cancers tested; 0.25 % in 589 stomach cancers tested; 0.15 % in 603 endometrium cancers tested; 0.13 % in 273 cervix cancers tested; 0.08 % in 238 bone cancers tested; 0.08 % in 1634 lung cancers tested; 0.08 % in 1512 liver cancers tested; 0.08 % in 1316 breast cancers tested; 0.07 % in 548 urinary tract cancers tested; 0.06 % in 942 upper aerodigestive tract cancers tested; 0.04 % in 833 ovary cancers tested; 0.03 % in 710 oesophagus cancers tested; 0.03 % in 558 thyroid cancers tested; 0.03 % in 2103 central nervous system cancers tested; 0.03 % in 1276 kidney cancers tested; 0.02 % in 881 prostate cancers tested; 0.02 % in 2009 haematopoietic and lymphoid cancers tested.
Frequency of Mutated Sites:
None > 2 in 20,034 cancer specimens
Comments:
Only 1 deletion and 1 insertion, and no complex mutations are noted on the COSMIC website.