Nomenclature
Short Name:
SSTK
Full Name:
Serine-threonine protein kinase SSTK
Alias:
- Serine/threonine kinase FKSG82
- TSSK6
Classification
Type:
Protein-serine/threonine kinase
Group:
CAMK
Family:
TSSK
SubFamily:
NA
Structure
Mol. Mass (Da):
30,331
# Amino Acids:
273
# mRNA Isoforms:
1
mRNA Isoforms:
30,331 Da (273 AA; Q9BXA6)
4D Structure:
Interacts with the heatshock proteins HSPCB, HSPA8 and HAPA1A. These interactions appear to be required for TSSK6 kinase activity
1D Structure:
Subfamily Alignment
Domain Distribution:
| Start | End | Domain |
|---|---|---|
| 12 | 267 | Pkinase |
Distribution
Based on gene microarray analysis from the NCBI
Human Tissue Distribution
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
43
786
18
361
0.3
5
6
5
1
25
1
0
2
41
79
224
21
386
27
207
0.2
3
27
3
0.2
4
33
4
2
44
8
54
0.1
2
3
1
0.7
13
80
16
2
38
8
50
41
763
26
511
3
63
1
0
0.1
2
3
0
2
36
8
49
0.2
3
15
2
2
44
96
29
0.3
5
4
4
0.8
14
58
12
17
312
87
191
1
24
8
35
1
19
8
24
0.9
16
1
0
14
257
4
111
1
25
8
33
30
562
52
476
0.2
4
4
3
0.3
5
4
6
0.4
8
4
12
5
92
42
79
42
778
12
46
36
660
21
1432
0.1
2
36
0
33
610
78
528
100
1845
46
4365
Evolution
Species Conservation
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
100
100
100
55.3
62.2
100
99.6
99.6
-
-
-
98.5
-
-
98
97.8
99.2
98
-
-
-
97
99.2
97
-
-
97
-
-
-
71.2
77.4
-
-
-
73
-
-
-
-
-
51.5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
21.8
34.3
-
-
-
-
-
-
-
For a wider analysis go to PhosphoNET Evolution in PhosphoNET
Binding Proteins
Examples of known interacting proteins
hiddentext
| No. | Name – UniProt ID |
|---|---|
| 1 | HSPA8 - P11142 |
Regulation
Activation:
NA
Inhibition:
NA
Synthesis:
NA
Degradation:
NA
Protein Kinase Specificity
Matrix of observed frequency (%) of amino acids in aligned protein substrate phosphosites
Matrix Type:
Predicted from the application of the Kinexus Kinase Substrate Predictor Version 2.0 algorithm, which was trained with over 10,000 kinase-protein substrate pairs and 8,000 kinase-peptide substrate pairs.
Domain #:
1
Disease Linkage
General Disease Association:
Reproductive disorder
Specific Diseases (Non-cancerous):
Oligospermia
Comments:
SSTK is a protein-serine/threonine kinase that is testis-specific and is required for sperm production and function. Male mice absent with this gene are highly sterile and have morphologically abnormal sperm.
Gene Expression in Cancers:
The COSMIC website notes an up-regulated expression score for SSTK in diverse human cancers of 517, which is 1.1-fold of the average score of 462 for the human protein kinases. The down-regulated expression score of 6 for this protein kinase in human cancers was 0.1-fold of the average score of 60 for the human protein kinases.
Mutagenesis Experiments:
Insertional mutagenesis studies in mice have not yet revealed a role for this protein kinase in mouse cancer oncogenesis.
Mutation Rate in All Cancers:
Percent mutation rates per 100 amino acids length in human cancers: 0.11 % in 24847 diverse cancer specimens. This rate is a modest 1.45-fold higher than the average rate of 0.075 % calculated for human protein kinases in general.
Mutation Rate in Specific Cancers:
Highest percent mutation rates per 100 amino acids length in human cancers: 0.93 % in 589 stomach cancers tested; 0.52 % in 1270 large intestine cancers tested; 0.36 % in 603 endometrium cancers tested; 0.27 % in 273 cervix cancers tested; 0.22 % in 1634 lung cancers tested; 0.17 % in 864 skin cancers tested; 0.15 % in 710 oesophagus cancers tested; 0.1 % in 382 soft tissue cancers tested; 0.09 % in 833 ovary cancers tested; 0.08 % in 881 prostate cancers tested; 0.08 % in 441 autonomic ganglia cancers tested; 0.07 % in 548 urinary tract cancers tested; 0.07 % in 1062 upper aerodigestive tract cancers tested; 0.05 % in 2009 haematopoietic and lymphoid cancers tested.
Frequency of Mutated Sites:
Most frequent mutations with the number of reports indicated in brackets: R149H (3).
Comments:
No deletions, insertions or complex mutations are noted on the COSMIC website.