Nomenclature
Short Name:
SgK069
Full Name:
SH3-binding domain kinase family member 2
Alias:
- SgK069 (2nd kinase domain) with SgK110 (first kinase domain)
- AC008735_EP
- SBK2
- Sugen kinase 69
Classification
Type:
Protein-serine/threonine kinase
Group:
Other
Family:
NKF1
SubFamily:
NA
Structure
Mol. Mass (Da):
38,088
# Amino Acids:
348
# mRNA Isoforms:
1
mRNA Isoforms:
38,088 Da (348 AA; P0C263)
4D Structure:
NA
1D Structure:
Subfamily Alignment
Domain Distribution:
| Start | End | Domain |
|---|---|---|
| 62 | 327 | Pkinase |
Post-translation Modifications
For detailed information on phosphorylation of this kinase go to PhosphoNET
Distribution
Based on gene microarray analysis from the NCBI
Human Tissue Distribution
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
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Evolution
Species Conservation
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
100
100
100
56.2
56.6
97
71.2
72.2
95
-
-
78
-
-
-
37.7
40.9
84
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81.6
89
82
78.7
85.9
81
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33.8
50
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56
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52
35
50.6
45
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23.1
39.8
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For a wider analysis go to PhosphoNET Evolution in PhosphoNET
Regulation
Activation:
NA
Inhibition:
NA
Synthesis:
NA
Degradation:
NA
Protein Kinase Specificity
Matrix of observed frequency (%) of amino acids in aligned protein substrate phosphosites
Matrix Type:
Predicted from the application of the Kinexus Kinase Substrate Predictor Version 2.0 algorithm, which was trained with over 10,000 kinase-protein substrate pairs and 8,000 kinase-peptide substrate pairs.
Domain #:
1
Disease Linkage
Gene Expression in Cancers:
The COSMIC website notes an up-regulated expression score for SgK069 in diverse human cancers of 343, which is 0.7-fold of the average score of 462 for the human protein kinases. The down-regulated expression score of 0 for this protein kinase in human cancers was 100% lower than the average score of 60 for the human protein kinases.
Mutagenesis Experiments:
Insertional mutagenesis studies in mice have not yet revealed a role for this protein kinase in mouse cancer oncogenesis.
Mutation Rate in All Cancers:
Percent mutation rates per 100 amino acids length in human cancers: 0.09 % in 24501 diverse cancer specimens. This rate is only 25 % higher than the average rate of 0.075 % calculated for human protein kinases in general.
Mutation Rate in Specific Cancers:
Highest percent mutation rates per 100 amino acids length in human cancers: 0.57 % in 864 skin cancers tested; 0.34 % in 1270 large intestine cancers tested; 0.25 % in 575 stomach cancers tested; 0.24 % in 833 ovary cancers tested; 0.19 % in 603 endometrium cancers tested; 0.19 % in 1512 liver cancers tested; 0.12 % in 942 upper aerodigestive tract cancers tested; 0.12 % in 710 oesophagus cancers tested; 0.11 % in 273 cervix cancers tested; 0.09 % in 1634 lung cancers tested; 0.06 % in 2060 central nervous system cancers tested.
Frequency of Mutated Sites:
Most frequent mutations with the number of reports indicated in brackets: S129L (6); R313Q (3).
Comments:
No deletions, insertions or complex mutations are noted on the COSMIC website.