Nomenclature
Short Name:
SgK495
Full Name:
SINK-homologous serine-threonine kinase
Alias:
- FLJ00113
- SHIK
- STK40
- DKFZp762O044
Classification
Type:
Protein-serine/threonine kinase
Group:
CAMK
Family:
CAMK-Unique
SubFamily:
NA
Structure
Mol. Mass (Da):
49,001
# Amino Acids:
435
# mRNA Isoforms:
4
mRNA Isoforms:
49,459 Da (440 AA; Q8N2I9-4); 49,001 Da (435 AA; Q8N2I9); 46,393 Da (417 AA; Q8N2I9-3); 18,956 Da (173 AA; Q8N2I9-2)
4D Structure:
NA
1D Structure:
3D Image (rendered using PV Viewer):
PDB ID
Subfamily Alignment
Domain Distribution:
| Start | End | Domain |
|---|---|---|
| 37 | 331 | Pkinase |
Post-translation Modifications
For detailed information on phosphorylation of this kinase go to PhosphoNET
Acetylated:
K30, K199.
Serine phosphorylated:
S95, S422.
Distribution
Based on gene microarray analysis from the NCBI
Human Tissue Distribution
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
100
1824
15
1323
1
24
5
16
-
-
-
-
31
561
60
1624
45
826
23
580
3
48
18
44
2
32
23
25
9
172
7
260
1
22
3
1
4
73
55
108
5
94
7
131
36
665
30
610
-
-
-
-
0.9
17
3
0
14
247
7
392
2
30
10
18
36
656
79
2499
0.5
10
3
5
9
161
39
88
46
844
59
559
8
142
7
140
8
146
7
213
-
-
-
-
5
100
3
5
8
147
7
177
51
929
37
1150
1
22
3
2
2
28
3
8
1
27
3
2
7
130
28
119
49
897
12
26
6
108
16
89
14
263
95
826
46
836
52
589
26
472
35
425
Evolution
Species Conservation
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
100
100
100
0
0
99.5
25.5
39.5
99
-
-
35
-
-
-
84.5
84.8
98
-
-
-
97.2
99
97
97.2
99.3
97
-
-
-
90.8
96.5
-
89.8
96
90
83.9
93
87
83.9
92.6
85
-
-
-
-
-
-
-
-
-
-
-
-
39.9
48.2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
For a wider analysis go to PhosphoNET Evolution in PhosphoNET
Regulation
Activation:
NA
Inhibition:
NA
Synthesis:
NA
Degradation:
NA
Protein Kinase Specificity
Matrix of observed frequency (%) of amino acids in aligned protein substrate phosphosites
Matrix Type:
Predicted from the application of the Kinexus Kinase Substrate Predictor Version 2.0 algorithm, which was trained with over 10,000 kinase-protein substrate pairs and 8,000 kinase-peptide substrate pairs.
Domain #:
1
Disease Linkage
Comments:
Absence of STK40 protein in mice can cause respiratory failure and death at birth.
Gene Expression in Cancers:
The COSMIC website notes an up-regulated expression score for SgK495 in diverse human cancers of 410, which is 0.9-fold of the average score of 462 for the human protein kinases. The down-regulated expression score of 50 for this protein kinase in human cancers was 0.8-fold of the average score of 60 for the human protein kinases.
Mutagenesis Experiments:
Insertional mutagenesis studies in mice have not yet revealed a role for this protein kinase in mouse cancer oncogenesis.
Mutation Rate in All Cancers:
Percent mutation rates per 100 amino acids length in human cancers: 0.09 % in 24591 diverse cancer specimens. This rate is only 16 % higher than the average rate of 0.075 % calculated for human protein kinases in general.
Mutation Rate in Specific Cancers:
Highest percent mutation rates per 100 amino acids length in human cancers: 0.45 % in 1229 large intestine cancers tested; 0.43 % in 864 skin cancers tested; 0.34 % in 603 endometrium cancers tested; 0.23 % in 589 stomach cancers tested; 0.19 % in 238 bone cancers tested; 0.14 % in 807 ovary cancers tested; 0.14 % in 1512 liver cancers tested; 0.11 % in 1608 lung cancers tested; 0.08 % in 273 cervix cancers tested; 0.06 % in 710 oesophagus cancers tested; 0.06 % in 1459 pancreas cancers tested; 0.05 % in 1329 kidney cancers tested.
Frequency of Mutated Sites:
Most frequent mutations with the number of reports indicated in brackets: M133V (4); A320V (3).
Comments:
No deletions, insertions or complex mutations are noted on the COSMIC website.