Nomenclature
Short Name:
Trb3
Full Name:
Tribbles homolog 3
Alias:
- TRB-3
- Neuronal cell death inducible putative kinase
- p65-interacting inhibitor of NF-kappaB
- SINK
- TRIB3
- LOC57761
Classification
Type:
Protein-serine/threonine kinase
Group:
CAMK
Family:
Trbl
SubFamily:
NA
Structure
Mol. Mass (Da):
39,578
# Amino Acids:
358
# mRNA Isoforms:
1
mRNA Isoforms:
39,578 Da (358 AA; Q96RU7)
4D Structure:
Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7.
1D Structure:
Subfamily Alignment
Domain Distribution:
| Start | End | Domain |
|---|---|---|
| 68 | 315 | Pkinase |
Post-translation Modifications
For detailed information on phosphorylation of this kinase go to PhosphoNET
Serine phosphorylated:
S12, S215.
Threonine phosphorylated:
T64.
Distribution
Based on gene microarray analysis from the NCBI
Human Tissue Distribution
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
% Max Expression:
Mean Expression:
Number of Samples:
Standard Deviation:
91
1496
22
2434
8
139
9
62
3
50
5
45
13
205
67
432
53
871
21
515
4
64
46
48
2
28
25
21
29
474
19
636
13
217
10
158
4
66
37
55
30
492
16
424
55
896
73
657
5
82
16
40
4
70
6
36
11
173
13
141
4
65
12
64
5
84
82
76
9
147
10
98
5
76
40
36
32
527
79
450
3
53
12
58
8
135
14
105
3
56
6
69
4
60
9
77
5
78
12
43
37
611
42
624
7
110
19
57
6
90
10
62
4
70
10
47
17
274
14
94
59
968
18
653
31
506
26
634
100
1636
68
1904
45
735
52
624
13
205
35
160
Evolution
Species Conservation
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:
100
100
100
44.4
60
95
93.5
95.8
94
-
-
83
-
-
-
82.1
87.9
83
-
-
-
73.7
82.1
74.5
73.4
81
74.5
-
-
-
45.5
59.5
-
24.3
39
-
23.7
37.2
-
49.1
64.5
57
-
-
-
-
-
-
-
-
-
-
-
-
41.3
53.9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
For a wider analysis go to PhosphoNET Evolution in PhosphoNET
Regulation
Activation:
NA
Inhibition:
NA
Synthesis:
By hypoxia, TNF and by nutrient starvation. Expression is PI 3-kinase and/or NF-kappa-B-dependent.
Degradation:
NA
Protein Kinase Specificity
Matrix of observed frequency (%) of amino acids in aligned protein substrate phosphosites
Matrix Type:
Predicted from the application of the Kinexus Kinase Substrate Predictor Version 2.0 algorithm, which was trained with over 10,000 kinase-protein substrate pairs and 8,000 kinase-peptide substrate pairs.
Domain #:
1
Disease Linkage
General Disease Association:
Endocrine disorders
Specific Diseases (Non-cancerous):
Insulin resistance; Anoxia
Comments:
Insulin Resistance occurs when cells cannot respond to insulin, which leads to improper glycogen management. Anoxia is characterized by the insufficient supply of oxygen to the brain which can be characterized by poor judgement, inattentiveness, memory impairment, and reduced motor coordination.
Mutagenesis Experiments:
Insertional mutagenesis studies in mice have not yet revealed a role for this protein kinase in mouse cancer oncogenesis.
Mutation Rate in All Cancers:
Percent mutation rates per 100 amino acids length in human cancers: 0.09 % in 24752 diverse cancer specimens. This rate is only 19 % higher than the average rate of 0.075 % calculated for human protein kinases in general.
Mutation Rate in Specific Cancers:
Highest percent mutation rates per 100 amino acids length in human cancers: 0.46 % in 1093 large intestine cancers tested; 0.17 % in 1620 lung cancers tested.
Frequency of Mutated Sites:
None > 4 in 20,035 cancer specimens
Comments:
Only 1 deletion and 1 insertion, and no complex mutations are noted on the COSMIC website.