KinaseNET

Nomenclature

Short Name:

ERK1

Full Name:

Mitogen-activated protein kinase 3

Alias:

EC 2.7.11.24
MAP kinase 1
MAPK 1
MAPK1
MAPK3; PRKM3; p44ERK1; p44MAPK
ERK-1
ERT2
Extracellular signal regulated kinase 1
Insulin-stimulated MAP2 kinase
Kinase ERK1

Classification

Type:

Protein-serine/threonine kinase

Group:

CMGC

Family:

MAPK

SubFamily:

ERK

Specific Links

BioCarta Entry:	erk pathway
Entrez-Gene Entry:	5595
Entrez-Protein Entry:	AAA36142.1
GeneCards Entry:	ERK1
KinBASE Entry:	ERK1
OMIM Entry:	601795
Pfam Entry:	P27361
PhosphoNET Entry:	P27361
Phosphosite Plus Entry:	595
ScanSite Entry:	P27361
Source Entry:	MAPK3
UniProt Entry:	P27361
Kinexus Products:	ERK1 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) pan-specific antibody AB-NK055-1 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) pan-specific antibody AB-NK055-2 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) pan-specific antibody AB-NK055-3 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) pan-specific antibody AB-NK055-4 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) pan-specific antibody AB-NK055-5 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) pan-specific antibody AB-NK055-6 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) pan-specific antibody AB-NK055-7 Mitogen-activated protein kinase 3 pan-specific antibody AB-NK055/56-2 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) T202+Y204 phosphosite-specific antibody AB-PK621 Extracellular regulated protein-serine kinase 2 (p42 MAP kinase) T185+Y187 phosphosite-specific antibody AB-PK622 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) Y204 phosphosite-specific antibody AB-PK864 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) T207 phosphosite-specific antibody AB-PK865 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) Y204+T207 phosphosite-specific antibody AB-PK866 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) S74 phosphosite-specific antibody AB-PK867 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (G8-K32, human) peptide - Powder PE-01AQS95 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (G8-K32, human) peptide - Powder PE-01AQS95 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (G23-D37, human) peptide - Powder PE-01AXB99 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (S286-D300, human) peptide - Powder PE-01AXC95 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (T337-E351, human) peptide - Powder PE-01AXD99 ERKSubtide - ERK1 (MAPK3) protein kinase substrate peptide - Powder PE-01BHI85 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (L201-T207, human) pT202+pY204 phosphopeptide - Powder PE-04ACU90 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (Y204-W209, human) pT207 phosphopeptide - Powder PE-04ATJ95 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (Y204-W209, human) pY204 phosphopeptide - Powder PE-04ATK95 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (Y204-W209, human) pY204+pT207 phosphopeptide - Powder PE-04ATL90 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (H195-A206, human) pT198+pT202+pY204 phosphopeptide - Powder PE-04ATM90 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (Y204-P213, human) pT204+pT207+pY210 phosphopeptide - Powder PE-04ATO95 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (V205-P213, human) pT207+pY210 phosphopeptide - Powder PE-04ATP01 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (H195-L201, human) pT198 phosphopeptide - Powder PE-04AZG00 Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (Y204-Y210, human) pT204+pT207 phosphopeptide - Powder PE-04AZH00 ERKSelectideA - ERK1 (MAPK3) protein kinase substrate peptide - Powder PE-14CAA95 ERKSelectideB - ERK1 (MAPK3) protein kinase substrate peptide - Powder PE-14CAB95

General Links

Structure

Mol. Mass (Da):

43,136

# Amino Acids:

379

# mRNA Isoforms:

mRNA Isoforms:

43,136 Da (379 AA; P27361); 40,088 Da (357 AA; P27361-3); 38,275 Da (335 AA; P27361-2)

4D Structure:

Interacts with MORG1 By similarity. Binds to HIV-1 Nef. This interaction inhibits its kinase activity. Interacts with HSF4 and NISCH. Interacts with ARRB2. Interacts with ADAM15.

1D Structure:

Retrieve Gene Sequence
Retrieve Full Protein Sequence
Retrieve Catalytic Domain Sequence

3D Image (rendered using PV Viewer):

PDB ID

2ZOQ

Subfamily Alignment

Domain Distribution:

Start	End	Domain
42	330	Pkinase

Kinexus Products

Click on entries below for direct links to relevant products from Kinexus for this protein kinase.

hiddentext

○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) pan-specific antibody AB-NK055-1
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) pan-specific antibody AB-NK055-2
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) pan-specific antibody AB-NK055-3
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) pan-specific antibody AB-NK055-4
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) pan-specific antibody AB-NK055-5
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) pan-specific antibody AB-NK055-6
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) pan-specific antibody AB-NK055-7
○	Mitogen-activated protein kinase 3 pan-specific antibody AB-NK055/56-2
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) T202+Y204 phosphosite-specific antibody AB-PK621
○	Extracellular regulated protein-serine kinase 2 (p42 MAP kinase) T185+Y187 phosphosite-specific antibody AB-PK622
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) Y204 phosphosite-specific antibody AB-PK864
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) T207 phosphosite-specific antibody AB-PK865
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) Y204+T207 phosphosite-specific antibody AB-PK866
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) S74 phosphosite-specific antibody AB-PK867
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (G8-K32, human) peptide - Powder PE-01AQS95
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (G8-K32, human) peptide - Powder PE-01AQS95
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (G23-D37, human) peptide - Powder PE-01AXB99
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (S286-D300, human) peptide - Powder PE-01AXC95
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (T337-E351, human) peptide - Powder PE-01AXD99
○	ERKSubtide - ERK1 (MAPK3) protein kinase substrate peptide - Powder PE-01BHI85
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (L201-T207, human) pT202+pY204 phosphopeptide - Powder PE-04ACU90
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (Y204-W209, human) pT207 phosphopeptide - Powder PE-04ATJ95
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (Y204-W209, human) pY204 phosphopeptide - Powder PE-04ATK95
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (Y204-W209, human) pY204+pT207 phosphopeptide - Powder PE-04ATL90
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (H195-A206, human) pT198+pT202+pY204 phosphopeptide - Powder PE-04ATM90
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (Y204-P213, human) pT204+pT207+pY210 phosphopeptide - Powder PE-04ATO95
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (V205-P213, human) pT207+pY210 phosphopeptide - Powder PE-04ATP01
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (H195-L201, human) pT198 phosphopeptide - Powder PE-04AZG00
○	Extracellular regulated protein-serine kinase 1 (p44 MAP kinase) (Y204-Y210, human) pT204+pT207 phosphopeptide - Powder PE-04AZH00
○	ERKSelectideA - ERK1 (MAPK3) protein kinase substrate peptide - Powder PE-14CAA95
○	ERKSelectideB - ERK1 (MAPK3) protein kinase substrate peptide - Powder PE-14CAB95

Post-translation Modifications

For detailed information on phosphorylation of this kinase go to PhosphoNET

Acetylated:

K181.

Serine phosphorylated:

S58, S170, S219+, S283+.

Threonine phosphorylated:

T17, T80, T198+, T202+, T207-, T223, T368.

Tyrosine phosphorylated:

Y53-, Y130, Y204+, Y210-, Y222.

Ubiquitinated:

K72, K181, K220, K287, K294.

Distribution

Based on gene microarray analysis from the NCBI

Human Tissue Distribution

% Max Expression:

Mean Expression:

Number of Samples:

Standard Deviation:

26

944

16

1081
3

115

10

87
4

155

1

0
18

660

46

585
25

885

14

855
94

3369

45

7350
16

586

19

694
26

927

21

1161
24

873

10

775
6

218

45

244
3

93

14

115
23

837

94

707
2

75

12

31
3

93

9

88
2

85

11

95
6

230

8

138
6

229

99

79
3

118

8

160
3

94

50

86
19

684

56

682
8

279

10

266
5

191

12

199
10

355

10

87
4

133

8

138
3

112

10

98
25

879

28

915
3

100

15

67
2

88

8

101
5

185

8

164
4

125

14

62
38

1355

18

965
35

1255

21

1388
5

168

57

367
21

741

31

705
100

3570

22

6888

Evolution

Species Conservation

PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:

100

100

100
95.8

96.8

97
-

-

99
-

-

98
-

-

-
96.3

97.6

97
-

-

-
96.8

97.1

97
97.1

97.4

97
-

-

-
-

-

-
83.1

88.4

-
82.3

87.6

-
82.4

87.2

88
-

-

-
68.5

75.6

-
78.4

84.4

-
62.2

72.5

-
77.6

84.4

-
-

-

-
-

-

-
-

-

49
48.5

66.8

50
47.2

63.9

52.5
46.2

62.5

59

For a wider analysis go to PhosphoNET Evolution in PhosphoNET

Binding Proteins

Examples of known interacting proteins

hiddentext

No.	Name – UniProt ID
1	ELK1 - P19419
2	MAP2K1 - Q02750
3	MAP2K2 - P36507
4	PTPN7 - P35236
5	DUSP6 - Q16828
6	DUSP1 - P28562
7	PTPRR - Q15256
8	SREBF1 - P36956
9	RPS6KA3 - P51812
10	RPS6KA1 - Q15418
11	DUSP4 - Q13115
12	RAF1 - P04049
13	HSF1 - Q00613
14	MYC - P01106
15	GTF2I - P78347

Regulation

Activation:

Phosphorylation at Thr-202 and Tyr-204 increases phosphotransferase activity.

Inhibition:

Synthesis:

Degradation:

Kinections Map

Click here to download a PPT of the image below

Known Upstream Kinases

For further details on these substrates click on the Substrate Short Name or UniProt ID. Phosphosite Location is hyperlinked to PhosphoNET predictions.

Based on in vitro and/or in vivo phosphorylation data

Kinase Short Name	UniProt ID (Human)	Phosphosite Location	Phosphosite Sequence	Effect of Phosphorylation

ERK1	P27361	T17	GGGEPRRTEGVGPGV
ERK1	P27361	T198	ADPEHDHTGFLTEYV	?
ERK1	P27361	T202	HDHTGFLTEYVATRW	+
MEK2	P36507	T202	HDHTGFLTEYVATRW	+
MEK1	Q02750	T202	HDHTGFLTEYVATRW	+
ERK1	P27361	Y204	HTGFLTEYVATRWYR	+
LCK	P06239	Y204	HTGFLTEYVATRWYR	+
JAK2	O60674	Y204	HTGFLTEYVATRWYR	+
MEK2	P36507	Y204	HTGFLTEYVATRWYR	+
MEK1	Q02750	Y204	HTGFLTEYVATRWYR	+
ERK1	P27361	T207	FLTEYVATRWYRAPE	-
ERK1	P27361	T368	KELIFQETARFQPGV

Known Downstream Substrates

For further details on these substrates click on the Substrate Short Name or UniProt ID. Phosphosite Location is hyperlinked to PhosphoNET predictions.

Based on in vitro and/or in vivo phosphorylation data

Substrate Short Name	UniProt ID (Human)	Phosphosite Location	Phosphosite Sequence	Effect of Phosphorylation

FBXL14	Q8N1E6	S236	GLRLLNLSFCGGISD
FBXL14	Q8N1E6	S257	SHMGSLRSLNLRSCD
FHOD1	Q9Y613	S498	PAARTPQSPAPCVLL
FIP1L1	Q6UN15	T494	RERDHSPTPSVFNSD
FKBP7	Q9Y680	S247	HDGDGFISPKEYNVY
FLNA	P21333	S1084	LQGGSAGSPARFTID
FLNA	P21333	S1734	GGEHVPNSPFQVTAL
FLNA	P21333	S1946	NEQHVPGSPFTARVT
FLNA	P21333	S757	GGVSIPNSPFRVNVG
FLNA	P21333	S959	GGDPIPKSPFSVAVS
FLNB	O75369	S1505	ADEEIPRSPFKVKVL
FLNB	O75369	S833	ASQEIPASPFRVKVD
FLNB	O75369	S932	GGDPIPKSPFTVGVA
FLNC	Q14315	S1527	ADQEVPRSPFKIKVL
FLNC	Q14315	S2362	NDEHIPDSPFVVPVA
FLNC	Q14315	S2718	GDESVPGSPFKVKVP
FLNC	Q14315	S954	GGDPVPKSPFVVNVA
FLNC	Q14315	T1079	LKGGLVGTPAPFSID
Fos	P01100	S374	PSSDSLSSPTLLAL_	+
Fos	P01100	T232	GGLPEVATPESEEAF	+
Fos	P01100	T325	TELEPLCTPVVTCTP
Fos	P01100	T331	CTPVVTCTPSCTAYT
FOXC1	Q12948	S241	PSPPQPLSPAAALGS
FOXK1	P85037	S428	PTHPGLMSPRSGGLQ
FOXK2	Q01167	S424	QEARFAQSAPGSPLS
FOXO3 (FKHRL1)	O43524	S294	QLSKWPGSPTSRSSD	-
FOXO3 (FKHRL1)	O43524	S344	QDDDAPLSPMLYSSS	-
FOXO3 (FKHRL1)	O43524	S425	TKGSGLGSPTSSFNS	-
FTSJD2	Q8N1G2	S38	SDDEPPSSVSHGAKA
FUS	P35637	S346	VSFDDPPSAKAAIDW
G3BP1	Q13283	S232	EDAQKSSSPAPADIA	-
GAB1	Q13480	T476	EANYVPMTPGTFDFS
GAB2	Q9UQC2	S623	ALDFQPSSPSPHRKP
GABRA1	P14867	T376	APTATSYTPNLARGD
GAP43	P17677	S151	TKASTDNSPSSKAED
GATA1	P15976	S178	TFFSPTGSPLNSAAY
GATA1	P15976	S26	VDPALVSSTPESGVF
GATA6	Q92908	S266	VSARFPYSPSPPMAN
GATAD2B	Q8WXI9	S135	LSDNEASSPRSSSRM
GBF1	Q92538	S1761	PPPPEIPSELGACDF
GBF1	Q92538	S314	TDLEQPGSPGYSTAT
GCFC	Q9Y5B6	T68	PSPPSALTPGLGAEA
GDI1	P31150	T165	FEGVDPQTTSMRDVY
GMNN	O75496	S60	HRNDHLTSTTSSPGV
GMNN	O75496	S63	DHLTSTTSSPGVIVP
GORASP2	Q9H8Y8	T222	LPGQMAGTPITPLKD
GORASP2	Q9H8Y8	T225	QMAGTPITPLKDGFT
GPKOW	Q92917	T12	KEGVLPLTAASTAPI
GRASP65	Q9BQQ3	S273	DPLPGPGSPSHSAPD
Grb10	Q13322	S150	PELCGPGSPPVLTPG	-
Grb10	Q13322	S418	QQRKALLSPFSTPVR
Grb10	Q13322	S476	MNILGSQSPLHPSTL	-
GRIPAP1	Q4V328	S655	LVLSEMNSPSRTQTG
GSK3b	P49841	T43	KVTTVVATPGQGPDR
GTF2I	P78347	S210	DADRSILSPGGSCGP
GTF2I	P78347	S668	INTKALQSPKRPRSP
GTF2I	P78347	S674	QSPKRPRSPGSNSKV
H3.2	P84228	S29	ATKAARKSAPATGGV
HADH	Q16836	S290	ENPLHQPSPSLNKLV
HAUS6	Q7Z4H7	S805	NFKLEPNSPMHGGTL
HBS1L	Q9Y450	S229	IQASEEQSSTPAPVK
HBS1L	Q9Y450	S230	QASEEQSSTPAPVKK
HCFC1	P51610	S1507	PPEELQVSPGPRQQL
HCFC1	P51610	S598	ATVKVASSPVMVSNP
HePTP	P35236	S93	ALQRQPPSPKQLEEE	-
HePTP	P35236	T66	EPICSVNTPREVTLH	-
HIBADH	P31937	S88	AGEQVVSSPADVAEK
HINT1	P49773	S45	CLAFHDISPQAPTHF
HIRIP3	Q9BW71	S108	ESGSEASSPDYFGPP
HMGA1	P17096	S36	PRKQPPVSPGTALVG
hnRNP K	P61978	S284	RRDYDDMSPRRGPPP
hnRNP K	P61978	S353	DSAIDTWSPSEWQMA
HNRNPA1	P09651	S6	__MSKSESPKEPEQL
HNRNPD	Q14103	T193	VGGLSPDTPEEKIRE
HNRNPH1	P31943	S104	LKHTGPNSPDTANDG
HNRNPL	P14866	S101	DPHKTPASPVVHIRG
HSF1	Q00613	S303	RVKEEPPSPPQSPRV	-
HSF1	Q00613	S307	EPPSPPQSPRVEEAS	-
HSL	Q05469	S900	GNSEPSDSPEMSQSM
HSL	Q05469	T590	NSETSSDTPEMSLSA
HSP90AB1	P08238	S67	TDPSKLDSGKELKID
HSPA9	P38646	T87	NAEGARTTPSVVAFT
HSPD1	P10809	S225	KFDRGYISPYFINTS
HSPD1	P10809	S70	IIEQSWGSPKVTKDG
IEX-1 (IER3)	P46695	T18	MTILQAPTPAPSTIP
IKK-gamma	Q9Y6K9	S377	PAPAYLSSPLALPSQ
ILF3	Q12906	S503	APVVEAVSTPSAAFP
ILF3	Q12906	T504	PVVEAVSTPSAAFPS
ILKAP	Q9H0C8	T315	DIRRCQLTPNDRFIL
ILKAP	Q9H0C8	T333	DGLFKVFTPEEAVNF
IMPDH2	P12268	S122	ITDPVVLSPKDRVRD
INCENP	Q9NQS7	S312	HSPIAPSSPSPQVLA
iNOS	P35228	S745	KSRQNLQSPTSSRAT
IQGAP2	Q13586	S575	LVEKLPDSPALAKKA
IRF-2	P14316	S18	WLEEQINSNTIPGLK
IRS1	P35568	S312	TESITATSPASMVGG	-
IRS1	P35568	S616	DDGYMPMSPGVAPVP	-
IRS4	O14654	S931	MDFTKRESNTPAPST
Irx2	Q9BZI1	S317	TPQGSRTSPGAPPPA
JAK2	O60674	S523	GVSDVPTSPTLQRPT	-
JMJD1B	Q7LBC6	T1307	GPGKLPQTPLDTGIP
Jun (c-Jun)	P05412	S243	PGETPPLSPIDMESQ	-
Jun (c-Jun)	P05412	S63	KNSDLLTSPDVGLLK	+
Jun (c-Jun)	P05412	S73	VGLLKLASPELERLI	+
JunD	P17535	S100	LGLLKLASPELERLI	+
JunD	P17535	S259	FGESPPLSPIDMDTQ
KFZp779A1753	P27816	S1121	PEAGAPTSASGLNGH
KFZp779A1753	P27816	S280	ALAKDMESPTKLDVT
KFZp779A1753	P27816	S507	VGLLKDMSPLSETEM
KFZp779A1753	P27816	S99	EGSDTTGSPTEFLEE
KHSRP	Q92945	T100	ATTVNNSTPDFGFGG
KIAA1671	Q9BY89	S1063	RKITPPSSPHSLTST
KIF4A	O95239	T1161	FFNPVCATPNSKILK
KLRG2	A4D1S0	S158	LTVPVPESPAFSRHA
KLRG2	A4D1S0	S95	GVCPEPPSPGPALVK
KPNA2	P52292	S62	SFPDDATSPLQENRN
KRT8	P05787	S432	SAYGGLTSPGLSYSL
KRT8	P05787	S74	TVNQSLLSPLVLEVD
Ksr1 (KSR)	Q8IVT5	S443	AMNHLDSSSNPSSTT
Kv4.2	Q9NZV8	S616	EGDDRPESPEYSGGN
Kv4.2	Q9NZV8	T602	TAIISIPTPPVTTPE
Kv4.2	Q9NZV8	T607	IPTPPVTTPEGDDRP
LARP1	Q6PKG0	S774	LPTTVPESPNYRNTR
LAT	O43561	T184	PSAPALSTPGIRDSA
Lck	P06239	S59	EGSNPPASPLQDNLV	?
LDH-B	P07195	T75	HGSLFLQTPKIVADK
LEMD3	Q9Y2U8	S402	GGAFSVDSPRIYSNS
LIFR	P42702	S1044	WNLVSPDSPRSIDSN
LIMA1	Q9UHB6	S362	PVHPKPLSPDSRASS
LIMA1	Q9UHB6	S490	NARETPHSPGVEDAP
LIMA1	Q9UHB6	S604	FQSTSVKSPKTVSPP
LIMD1	Q9UGP4	S424	VLLDSPSSPRVRLPC
LMNA	P02545	S22	QASSTPLSPTRITRL
LMNB1	P20700	S23	GGPTTPLSPTRLSRL
LMNB1	P20700	T20	SRAGGPTTPLSPTRL
LRRC16A	Q5VZK9	S1093	ILMTEEPSSPKGAVR
LRRIQ2	Q8IW35	S491	CPEPTIISAILKDDN
MAGED2	Q9UNF1	T42	QNVEVPETPKASKAL
MAP1B	P46821	S1396	SPIEKVLSPLRSPPL
MAP1B	P46821	S1797	RESSPLYSPTFSDST
MAP1B	P46821	S2209	PAPVQDRSPSPRHPD
MAP1B	P46821	T1788	KSDISPLTPRESSPL
MAP1B	P46821	T1853	ALNRDLSTPGLEKDS
MAP1S	Q66K74	S762	PAPASPGSSNDSSAR
MAP2	P11137	S136	ETANLPPSPPPSPAS
MAP2	P11137	T1616	YSSRTPGTPGTPSYP
MAP2	P11137	T1619	RTPGTPGTPSYPRTP
MAP7	Q14244	S657	GNGKPVGSPHVVTSH
MAP7D2	Q96T17	S721	NLIEGFNSPGQETPL
MAPKAPK2	P49137	T222	TSHNSLTTPCYTPYY	+
MAPKAPK2	P49137	T334	QSTKVPQTPLHTSRV	+
MARCKS	P29966	S101	AAPEAGASPVEKEAP
MARCKS	P29966	S118	GEAAEPGSPTAAEGE
MARCKS	P29966	S135	SAASSTSSPKAEDGA
MARCKS	P29966	S81	AAGSGAASPSAAEKG
MARCKS	P29966	T120	AAEPGSPTAAEGEAA
MARK2	Q7KZI7	S456	STAKVPASPLPGLER
MARK2	Q7KZI7	S619	PYGVTPASPSGHSQG
MARK4	Q96L34	S344	PSSPMVSSAHNPNKA
MAVS	Q7Z434	S222	TPSRGPVSPSVSFQP
MAZ	P56270	T72	AAPAPPPTPQAPAAE
MBD1	Q9UIS9	T570	EEAGGAGTPVITEIF
MBP	P02686	T232	KNIVTPRTPPPSQGK
MCL1	Q07820	T163	TDGSLPSTPPPAEEE
MCL1	Q07820	T92	EVPDVTATPARLLFF
MDC1	Q14676	S1068	LAPPPLLSPLLPSIK
MDC1	Q14676	T1343	TSTDQPVTPKPTSRT
MDC1	Q14676	T341	EEERIPATPVVIPMK
MDH2	P40926	T61	TLYDIAHTPGVAADL
MED1	Q15648	T611	LTSLLQITGNGGSTI
Meg-3	Q96TA1	S683	EASSPPASPLQHLLP
MEK1	Q02750	S25	SAVNGTSSAETNLEA
MEK1 (MAP2K1)	Q02750	T23	DGSAVNGTSSAETNL
MEK1 (MAP2K1)	Q02750	T292	ETPPRPRTPGRPLSS	+
MEK1 (MAP2K1)	Q02750	T386	IGLNQPSTPTHAAGV	?
MEPCE	Q7L2J0	T291	VPPTAPLTPLLHGEG
MFF	Q9GZY8	T138	DLERPPTTPQNEEIR
MGEA5	O60502	T709	FFQPPPLTPTSKVYT
MICALL1	Q8N3F8	S471	YGITPTSSPKTKKRP
MICALL1	Q8N3F8	S578	VEQMPQASPGLAPRT
MITF	O75030	S180	PGSSAPNSPMAMLTL	+
MKI67	P46013	S1131	TTKIACKSPPPESVD
MKI67	P46013	T1091	GMKKWPRTPKEEAQS
MKI67	P46013	T1139	PPPESVDTPTSTKQW
MKI67	P46013	T1335	GSKRRPQTPKEEAQA
MKI67	P46013	T1923	DINTFVGTPVEKLDL
MKL1	Q969V6	S454	TGSTPPVSPTPSERS
MKP3 (DUSP6)	Q16828	S159	DGSCSSSSPPLPVLG
MKP3 (DUSP6)	Q16828	S174	LGGLRISSDSSSDIE	-
MKP3 (DUSP6)	Q16828	S197	SATDSDGSPLSNSQP
MKP3 (DUSP6)	Q16828	S300	CLAGISRSVTVTVAY
MKP7 (DUSP16)	Q9BY84	S446	TNKLCQFSPVQELSE
MLLT4	P55196	S1698	DYEPPSPSPAPGAPP
MLLT4	P55196	S1721	YLKTQVLSPDSLFTA
MLLT4	P55196	T1352	TPAAIPATPVAVSQP
MNK1 (MKNK1)	Q9BUB5	T250	NSCTPITTPELTTPC	+
MNK1 (MKNK1)	Q9BUB5	T255	ITTPELTTPCGSAEY	+
MNK1 (MKNK1)	Q9BUB5	T385	APEKGLPTPQVLQRN	+
MNK2 (GPRK7)	Q9HBH9	T244	GDCSPISTPELLTPC	+
MNK2 (GPRK7)	Q9HBH9	T249	ISTPELLTPCGSAEY	+
MNK2 (GPRK7)	Q9HBH9	T379	APENTLPTPMVLQRN	+
MOGS	Q13724	T130	QQGTTPGTPKLRHTC
MPHOSPH6	Q99547	T147	EDENGDITPIKAKKM
MRPL40	Q9NQ50	S154	LEELQLESPKLHAEA
MRPS31	Q92665	S152	KKRIEPLSPELVAAA
MRPS31	Q92665	S274	EAPETDTSPSLWDVE
MSK1 (RPS6KA5)	O75582	S360	TEMDPTYSPAALPQS	+
MSK1 (RPS6KA5)	O75582	T581	PDNQPLKTPCFTLHY	+
MSK1 (RPS6KA5)	O75582	T700	LSSNPLMTPDILGSS	+
MSK2 (RPS6KA4)	O75676	S343	TRLEPVYSPPGSPPP	+
MSK2 (RPS6KA4)	O75676	T568	SPGVPMQTPCFTLQY	+
MSK2 (RPS6KA4)	O75676	T687	RSSPPLRTPDVLESS	+
MTA2	O94776	S435	RPEAQSLSPYTTSAN
MTDH	Q86UE4	S311	WNSVSPASAGKRKTE
MUC19	Q7Z5P9	T2309	PPVVKAQTTGPSAGV
MUC19	Q7Z5P9	T2327	SGQSARMTGASGPSV
Myb	P10242	S532	KIKQEVESPTDKSGN	-
Myc	P01106	S62	LLPTPPLSPSRRSGL
MYLK1 (smMLCK)	Q15746	S1779	SSTGSPTSPLNAEKL
MYST3	Q92794	S996	EEEEEPESPRSSSPP
MZF-1	P28698	S256	EEAGGIFSPGFALQL
MZF-1	P28698	S294	GLSGQIQSPSREGGF
MZF-1 iso2	P28698	S257	EEVGGIFSPGFTLQM
MZF-1 iso2	P28698	S275	TAEPDMMSPHLHVPW
MZF-1 iso2	P28698	S295	SLSGQIQSPTTEGGF
N-WASP (WAS-L)	O00401	T460	GQESTPPTPAPTSGI
NAP1L4	Q99733	T51	RLDNVPHTPSSYIET
NCAPH	Q15003	S81	DLQFSTDSPRLLASP
NCAPH	Q15003	T49	APLNIPGTPVLEDFP
NCL	P19338	T305	VEGTEPTTAFNLFVG
NCOA1	Q15788	S1185	GTPPASTSPFSQLAA
NCOA1	Q15788	T1179	NYGTNPGTPPASTSP
NCOA2	Q15596	S736	TIKQEPVSPKKKENA
NCOR1	O75376	S2184	EQRNDARSPGSISYL
NDE1	Q9NXR1	T215	ATGSVPSTPIAHRGP
NDEL1	Q9GZM8	T219	ASLSLPATPVGKGTE
NDRG3	Q9UGV2	S361	GTQESCESPDVLDRH
NFAT2	O95644	S172	YRDPSCLSPASSLSS
NFAT3	Q14934	S676	SNGRRKRSPTQSFRF	+
NNT	Q13423	S75	NEKRVALSPAGVQNL
NOL1	P46087	S732	TQTPAVLSPSKTQAT
NR0B2	Q15466	S26	AILYALLSSSLKAVP
NRXN2	Q9P2S2	S49	ARWAGAASSGELSFS
NSF	P46459	S547	LLEGPPHSGKTALAA
NUDT9	Q9BW91	S121	QISESNFSPKFNEKD
NUFIP2	Q7Z417	S349	VFPVDNSSAKIVPKI
NUMA1	Q14980	S1757	SVPGEPASPISQRLP
NUMA1	Q14980	S203	FLSGSPASPMGDILQ
NUP107	P57740	S11	SGFGEISSPVIREAE
NUP153	P49790	S1093	VEPASLPSASVFVLG
NUP153	P49790	S516	TNKVQMTSPSSTGSP
NUP153	P49790	S522	TSPSSTGSPMFKFSS
NUP153	P49790	S614	SVLDILKSPGFASPK
NUP153	P49790	S619	LKSPGFASPKIDSVA
NUP153	P49790	T388	VYFKPSLTPSGEFRK
NUP214	P35658	S1083	KHGAPSPSHPISAPQ
NUP35	Q8NFH5	S100	SIYDDISSPGLGSTP
NUP50	Q9UKX7	S221	KVAAETQSPSLFGST
NUP62	P37198	S408	KELEDLLSPLEELVK
NUP98	P52948	S612	LNNSNLFSPVNRDSE
NUP98	P52948	S623	RDSENLASPSEYPEN
OCLN	Q16625	S358	VQELPLTSPVDDFRQ
OGFR	Q9NZT2	S403	PTEPGPQSASEVEKI
OSR1	O95747	S359	AAISQLRSPRVKESI
OT1L1	Q8NHS2	T42	LAYRVCMTNEGHPWV
p27Kip1	P46527	S178	EENVSDGSPNAGSVE
p27Kip1	P46527	T187	NAGSVEQTPKKPGLR	+
p47phox	P14598	S345	QARPGPQSPGSPLEE	+
p47phox	P14598	S348	PGPQSPGSPLEEERQ
p53	P04637	S15	PSVEPPLSQETFSDL	+
p70S6K (RPS6KB1)	P23443	S434	SFEPKIRSPRRFIGS	+
p70S6K (RPS6KB1)	P23443	S447	GSPRTPVSPVKFSPG	+
p70S6K (RPS6KB1)	P23443	T444	RFIGSPRTPVSPVKF	+
PA1	Q9BTK6	S237	SEDPSPASPPLRSSG
PAI-RBP1	Q8NC51	S234	VKDELTESPKYIQKQ
PAICS	P22234	S27	EVYELLDSPGKVLLQ
PAPa	P51003	S537	DNSMSVPSPTSATKT
PARK7	Q99497	T154	EKDGLILTSRGPGTS
PCBP1	Q15365	S190	YQPMPASSPVICAGG
PCIF1	Q9H4Z3	T152	PSIPGTPTLKMWGTS
PCNP	Q8WW12	S142	IGRDTPTSAGPNSFN
PCNP	Q8WW12	T141	NIGRDTPTSAGPNSF
PCYT1A	P49585	S315	GRMLQAISPKQSPSS	-
PDCD4	Q53EL6	S80	RGDSVSDSGSDALRS
PDE4D iso1	Q08499	S715	YQSTIPQSPSPAPDD
PDE6G	P18545	T22	RVAGGPVTPRKGPPK
PDIA3	P30101	T120	GAYDGPRTADGIVSH
PDLIM5	Q96HC4	S111	VKPVPITSPAVSKVT
PEBP1	P30086	T42	DELGKVLTPTQVKNR
PEX19	P40855	S40	KPSPAPPSTTTAPDA
PGAM1	P18669	S31	GWYDADLSPAGHEEA
PHACTR4	Q8IZ21	S427	RIQQALTSPLPMTPI
PHACTR4	Q8IZ21	T432	LTSPLPMTPILEGSH
PHF2	O75151	T654	SKALRPPTSPGVFGA
PHF23	Q9BUL5	S153	ASPLSPTSLTHTSRP
PHGDH	O43175	S371	KNAGNCLSPAVIVGL
PI4K2A	Q9BTU6	S51	SGPSPPGSPGHDRER
PIP5KG	O60331	S650	DERSWVYSPLHYSAQ	-
PLCB1	Q9NQ66	S982	KKKSEPSSPDHGSST
PML	P29590	S36	PSEGRQPSPSPSPTE	+
PML	P29590	S38	EGRQPSPSPSPTERA	+
PML	P29590	S40	RQPSPSPSPTERAPA
PML	P29590	S527	PHLDGPPSPRSPVIG
PML	P29590	S530	DGPPSPRSPVIGSEV
PML	P29590	T28	PTMPPPETPSEGRQP
POLR2A	P24928	S1845	KYTPTSPSYSPSSPE
POLR2A	P24928	S1913	SPKYSPTSPTYSPTS
POLR2A	P24928	S1920	SPTYSPTSPKYSPTS
POLR2A	P24928	T1854	SPSSPEYTPTSPKYS
POM121B	A6NF01	T608	IVPAHVPTPIQPTFG
POM121B	A6NF01	T618	QPTFGGATHSAFGLK
PPA2	Q9H2U2	S317	LVESVSSSPNKESNE
PPAR-binding protein	Q15648	T1032	SSSNRPFTPPTSTGG
PPAR-binding protein	Q15648	T1457	HSKSPAYTPQNLDSE
PPARg-1	P37231	S112	AIKVEPASPPYYSEK	-
PPM1G	O15355	S243	EAGPSCSSASDKLPR
PPP1R10	Q96QC0	S297	GFLDALNSAPVPGIK
PPP1R13L	Q8WUF5	S120	SPKGRPSSPRTPLYL
PPP1R13L	Q8WUF5	S187	RAGSPRGSPLAEGPQ
PPP1R13L	Q8WUF5	T123	GRPSSPRTPLYLQPD
PPP1R1A	Q13522	S67	LKSTLAMSPRQRKKM
PPP1R2	P41236	S87	GDDEDACSDTEATEA
PPP1R9B	Q96SB3	S203	KLDADAVSPTVSQLS
PR	P06401	S294	APMAPGRSPLATTVM	?
PRCC	Q92733	S243	TTTTPSPSAIKAAAK
PRCC	Q92733	T72	PLLLPPPTGDPRLQP
PRDX3	P30048	S247	IKPSPAASKEYFQKV
PRKCSH	P14314	S442	QKPKLGGSPTSLGTW
PRPF4B	Q13523	S572	SEPSSPQSSTRTRSP
PRR12	Q9ULL5	S44	GLEPAAPSPRLRPEE
PRRT3	Q5FWE3	S439	PPPEPTASSMASAPA
PRRT3	Q5FWE3	S447	SMASAPASSPPANAT
PRRT3	Q5FWE3	T454	SSPPANATAPPLRWG
PTPRR	Q15256	T361	EPFVSIPTPREKVAM
PTPRR	Q15256	Y370	REKVAMEYLQSASRI
PTPRR	Q15256	Y44	SGKPVFIYKHSQDIE
PTPRR	Q15256	Y62	DIAPQKIYRHSYHSS
PUF60	Q9UHX1	T314	MPLLTPATPGGLPPA
PUM1	Q14671	S209	SEVNSVLSPRSESGG
PXN	P49023	S106	NPQDSVGSPCSRVGE
PXN	P49023	S130	KQKSAEPSPTVMSTS
PXN	P49023	S83	FIHQQPQSSSPVYGS
PYCR2	Q96C36	S304	VSTLTPSSPGKLLTR
Rab5A	P20339	S123	KELQRQASPNIVIAL
RAD23B	P54727	S160	AETPVATSPTATDST
RAD23B	P54727	T159	PAETPVATSPTATDS
Raf1	P04049	S289	RSHSESASPSALSSS	+
Raf1	P04049	S296	SPSALSSSPNNLSPT	-
Raf1	P04049	S301	SSSPNNLSPTGWSQP	-
RAI14	Q9P0K7	S281	KAPPPPISPTQLSDV
RAI14	Q9P0K7	S290	TQLSDVSSPRSITST
RanBP2	P49792	S1597	ETSKAPKSGFEGMFT
RanBP2	P49792	S2250	VHASPLASSPVRKNL
RanBP2	P49792	S2501	EVEVSSTSETTPKAV
RanBP2	P49792	T1396	PLAETVFTPKTSPEN
RAPH1	Q70E73	S1047	VLQQGCVSAKAPVLS
RARG2	P13631	S79	EMVPSSPSPPPPPRV	+
RASAL2	Q9UJF2	S21	RRSISGTSTSEKPNS
RASAL2	Q9UJF2	S23	SISGTSTSEKPNSMD
RBM14	Q96PK6	T165	AVQSGDKTKKPGAGD
RBM33	Q96EV2	S849	EQEEQALSPSPTNGN
RBM33	Q96EV2	T946	EEPAVPQTPRVASIQ
RBM9 iso6	O43251	T7	_MQNEPLTPGYHGFP
RBMX	P38159	S208	SRRDVYLSPRDDGYS
RCC1	P18754	T131	VSAGDSHTAALTDDG
RCC1	P18754	T79	AEAGGMHTVCLSKSG
RCN1	Q15293	T192	TATREEFTAFLHPEE
RCN1	Q15293	T76	SKTFDQLTPDESKER
RDBP	P18615	S353	GSLAVQNSPKGCHRD
REPS1	Q96D71	T481	GSDHTNPTSPLLVKP
RFC1	P35251	S156	KTKNKPLSPIKLTPT
RIF1	Q5UIP0	S1236	GSENRPFSPSPLNNI
RIF1	Q5UIP0	S1616	EEDVSIKSPICEKQD
RIF1	Q5UIP0	S2196	SQEDEISSPVNKVRR
RNF214	Q8ND24	S501	SQPSQPSSPLPGSHG
RP29	P30040	T249	QKSLNILTAFQKKGA
RPL12	P30050	S38	KIGPLGLSPKKVGDD
RPL18	Q07020	S130	FDQLALDSPKGCGTV
RPLP0	P05388	T286	APVAAATTAAPAAAA
RPLP2	P05387	S17	AALGGNSSPSAKDIK
RPN2	P04844	T521	VLSQNLFTPKQEIQH
RPRD2	Q5VT52	S614	SKASIGQSPGLPSTT
RPRD2	Q5VT52	S909	NCDRLSSSPGLFGAF
RPS3	P23396	T221	KDEILPTTPISEQKG
RPS3	P23396	T42	SGVEVRVTPTRTEII
RRBP1	Q9P2E9	S1277	IAGAPASSPEAPPAE
RRM2	P31350	S20	DPQQLQLSPLKGLSL
RRP12	Q5JTH9	T77	GKSEAPETPMEEEAE
RRP1B	Q14684	S706	TDKSILVSPTGPSRV
RRP1B	Q14684	T677	PAVQLNKTPSSSKKV
RSK1 (RPS6KA1)	Q15418	S363	TSRTPKDSPGIPPSA	+
RSK1 (RPS6KA1)	Q15418	T359	DTEFTSRTPKDSPGI	+
RSK1 (RPS6KA1)	Q15418	T573	AENGLLMTPCYTANF	+
RSK2 (RPS6KA3)	P51812	S386	HQLFRGFSFVAITSD	+
RSK2 (RPS6KA3)	P51812	T577	AENGLLMTPCYTANF	+
RTN2	O75298	S211	TPQLSPGSGTPQAGT
RTN2	O75298	S224	GTPSPSRSRDSNSGP
RXRa	P19793	S260	NMGLNPSSPNDPVTN	-
SCML2	Q9UQR0	S511	VPYVVPLSPKLPKTK
SCRIB	Q14160	T1342	DAPAQPPTPGPAASP
SEC16A	O15027	S1786	LPDGPLASPARVPMF
SEC16A	O15027	S1844	HLLQEARSPDPGIVP
SEC16A	O15027	S1905	TQPPLSLSPAPETKR
SEC16A	O15027	S23	GVVTPAASPSLPQPG
SEC16A	O15027	T1876	DGKFANLTPSRTVPD
SEC16A	O15027	T415	GSVSQPSTPSPPKPT
SEC24C	P53992	S328	LDPDAIPSPIQVIED
Securin	O95997	S165	LFQLGPPSPVKMPSP
SET	Q01105	S28	ALGPEETSASAGLPK
SETD1B	Q9UPS6	S1723	DKLRYLNSSRASTDE
SETD1B	Q9UPS6	Y1720	DKKDKLRYLNSSRAS
SF1	Q15637	S302	QRPGDPQSAQDKARM
SF3A1	Q15459	S413	APDEYLVSPITGEKI
SF3B1	O75533	T142	PFADGGKTPDPKMNV
SF3B1	O75533	T207	WDQTADQTPGATPKK
SF3B1	O75533	T211	ADQTPGATPKKLSSW
SF3B1	O75533	T223	SSWDQAETPGHTPSL
SF3B1	O75533	T227	QAETPGHTPSLRWDE
SF3B1	O75533	T261	WDPTPSHTPAGAATP
SF3B1	O75533	T278	GDTPGHATPGHGGAT
SF3B1	O75533	T313	HGSGWAETPRTDRGG
SF3B1	O75533	T326	GGDSIGETPTPGASK
SF3B1	O75533	T328	DSIGETPTPGASKRK
SF3B1	O75533	T434	PARKLTATPTPLGGM
SF3B2	Q13435	T780	EAMDGSETPQLFTVL
SFRS11	Q05519	S209	AAGLVSPSLKSDTSS
SH2-Bb	Q9NRF2	S96	PPILAPLSPGAEISP
Shc1	P29353	S36	TPPEELPSPSASSLG	-
SLC3A2	P08195	S607	QPGREEGSPLELERL
Smad2	Q15796	S245	NQSMDTGSPAELSPT
Smad2	Q15796	S250	TGSPAELSPTTLSPV
Smad2	Q15796	S255	ELSPTTLSPVNHSLD
Smad2	Q15796	T220	QSNYIPETPPPGYIS
Smad2	Q15796	T8	MSSILPFTPPVVKRL
SMAP2	Q8WU79	S219	DLLASVPSPSSSGSR
SMARCE1	Q969G3	S21	APATQMPSTPGFVGY
SMARCE1	Q969G3	T12	PSYAPPPTPAPATQM
Smc4	Q9NTJ3	S28	EEGPPPPSPDGASSD
SND1	Q7KZF4	S781	STRLGTLSPAFSTRV
SND1	Q7KZF4	T240	READGSETPEPFAAE
SNRPD2	P62316	S30	EFNTGPLSVLTQSVK
SNTB2	Q13425	S222	WEGAAPQSPSFSGSE
SNX2	O60749	T104	SPAVTPVTPTTLIAP
SON	P18583	S1697	QTLAALLSPKESSGG
SP1	P08047	S59	GGQESQPSPLALLAA
SP1	P08047	T453	SGPIIIRTPTVGPNG
SP1	P08047	T739	SEGSGTATPSALITT
SP3	Q02447	S73	CSKIGPPSPGDDEEE	?
SPAG9	O60271	T217	PAGDGLLTPDAQKGG
SPAG9	O60271	T226	DAQKGGETPGSEQWK
SPEN	Q96T58	S1278	EDEDPIGSPRLLSVK
SPHK1	Q9NYA1	S311	VGSKTPASPVVVQQG	+
SPHK2	Q9NRA0	S387	PATVEPASPTPAHSL
SPHK2	Q9NRA0	T614	AFRLEPLTPRGVLTV
SPT5	O00267	S666	VGGFAPMSPRISSPM
SPTBN1	Q01082-3	S14	SSISGPLSPAYTGQV
SREBP-2	Q12772	S432	NQNVLLMSPPASDSG
SREBP-2	Q12772	S455	SIDSEPGSPLLDDAK
SRRM1	Q8IYB3	S769	KKPPAPPSPVQSQSP
SRRM2	Q9UQ35	S1124	DRGEFSASPMLKSGM
SRRM2	Q9UQ35	S1188	PRQKDKFSPFPVQDR
SRRM2	Q9UQ35	S1320	EHKELSNSPLRENSF
SRRM2	Q9UQ35	S1329	LRENSFGSPLEFRNS
SRRM2	Q9UQ35	S2272	AAAMNLASPRTAVAP
SRRM2	Q9UQ35	S2326	TAANYPSSSRTPQAP
SRRM2	Q9UQ35	S2335	RTPQAPASANLVGPR
SRRM2	Q9UQ35	S2368	LAPASLTSARMAPAL
SRRM2	Q9UQ35	S2382	LSGANLTSPRVPLSA
SRRM2	Q9UQ35	S2388	TSPRVPLSAYERVSG
SRRM2	Q9UQ35	S2694	DSRSLSYSPVERRRP
SRRM2	Q9UQ35	T2247	MNLASARTPAIPTAV
SRRM2	Q9UQ35	T2289	VNLADPRTPTAPAVN
SRRM2	Q9UQ35	T2329	NYPSSSRTPQAPASA
SRRM2	Q9UQ35	T2347	GPRSAHATAPVNIAG
SSBP3	Q9BWW4	T360	GISNPPGTPRDDGEL
STAG2	Q8N3U4	T1112	SREQTLHTPVMMQTP
STAG2	Q8N3U4	T1118	HTPVMMQTPQLTSTI
StAR	P49675	S233	VLHPLAGSPSKTKLT
STAT1	P42224	S727	TDNLLPMSPEEFDEM	-
STAT3	P40763	S727	NTIDLPMSPRTLDSL	-
STAT5A	P42229	S726	TYMDQAPSPAVCPQA
STAT5A	P42229	S780	DSLDSRLSPPAGLFT	-
STK10	O94804	T952	AECPNPSTPSKAAKF
STK11IP	Q8N1F8	T460	NPLPATPTTSAPSAP
STMN1	P16949	S25	QAFELILSPRSKESV
STMN1	P16949	S38	SVPEFPLSPPKKKDL
STMN2	Q93045	S62	ELILKPPSPISEAPR
STMN2	Q93045	S73	EAPRTLASPKKKDLS
STOML2	Q9UJZ1	T327	TKAPVPGTPDSLSSG
STRN	O43815	S378	QPSVGSPSRPSSSRL
STUB1	Q9UNE7	S23	GGGSPEKSPSAQELK
SUDS3	Q9H7L9	T244	SPEHLPATPAESPAQ
Supervillin (ferret)	O95425	Y132	DPEADSEYLSRYTKS
SYAP1	Q96A49	S269	DEEEISTSPGVSEFV
SYN1	P17600	S551	PAARPPASPSPQRQA
SYN1	P17600	S62	SGVAPAASPAAPSPG
SYN1	P17600	S67	AASPAAPSPGSSGGG
SYN3	O14994	S470	PQGQQPLSPQSGSPQ
TACC1	O75410	S276	EELDENTSPLLGDAR
TACC3	Q9Y6A5	S71	PQTHRILSPSMASKL
TACC3	Q9Y6A5	T590	SMHGANETPSGRPRE
TAGLN2	P37802	S145	ARDDGLFSGDPNWFP
Tal1	P17542	S122	DGRMVQLSPPALAAP
Tau iso5 (Tau-C)	P10636-5	S202	SGYSSPGSPGTPGSR
Tau iso5 (Tau-C)	P10636-5	T205	SSPGSPGTPGSRSRT
Tau iso8	P10636-8	T181	KTPPAPKTPPSSGEP
Tau iso9 (Tau-F)	P10636-9	S404	PVVSGDTSPRHLSNV
TBRG4	Q969Z0	S553	AQPTGSQSPPPGSKR
TERF2	Q15554	S323	PTQALPASPALKNKR
TEX264	Q9Y6I9	S244	ETSAATLSPGASSRG
TFG	Q92734	S197	DQVSGPPSAPAEDRS
TFPT	P0C1Z6	S249	LPYPTLASPASD___
TH	P07101	S61	SYTPTPRSPRFIGRR
TH	P07101	S62	SYTPTPRSPRFIGRR
TH	P07101	T8	MPTPDATTPQAKGFR
TH iso3	P07101-3	S35	AIMVRGQSPRFIGRR
THOC2	Q8NI27	S1393	PVSGSLKSPVPRSDI
THOC3	Q96J01	S308	LWEVQCESPTFTVAW
THRAP3	Q9Y2W1	S243	ASAVSELSPRERSPA
THRAP3	Q9Y2W1	S253	ERSPALKSPLQSVVV
THRAP3	Q9Y2W1	T874	EEWDPEYTPKSKKYY
THRB	P10828	S142	IQKNLHPSYSCKYEG
TIF-IA	Q9NYV6	S633	SFDTHFRSPSSSVGS
TMED9	Q9BVK6	T80	REEYQPATPGLGMFV
TMF1	P82094	S72	KSNTEPQSPPIASPK
TMF1	P82094	S77	PQSPPIASPKAITKP
TMPO	P42167	S306	TGNFKHASPILPITE
TMPO	P42167	T160	GTESRSSTPLPTISS
TMPO	P42167	T355	MFPYEASTPTGISAS
TNF-R1	P19438	S286	FTPTLGFSPVPSSTF
TNF-R1	P19438	T276	PNPSFSPTPGFTPTL
TNF-R1	P19438	T280	FSPTPGFTPTLGFSP
TNKS1BP1	Q9C0C2	S1103	PQREAAFSPGQQDWS
TNKS1BP1	Q9C0C2	S1297	MAPGAVCSPGESKEL
TNKS1BP1	Q9C0C2	S228	SQEGPVKSPAECREE
TNKS1BP1	Q9C0C2	S437	EGVLQSPSQDQEKLG
TNKS1BP1	Q9C0C2	S601	EPLAGQESPLPLATR
TNKS1BP1	Q9C0C2	S712	AELKDTQSPSTCSEG
TNKS1BP1	Q9C0C2	S77	GPLAELPSARKMNML
TNKS1BP1	Q9C0C2	S983	WEFGKRDSLGAYASQ
TNKS1BP1	Q9C0C2	T501	SPPPSPITEASEAAE
TNRC6B	Q9UPQ9	S1816	EDPHRMGSPAPLLPG
TOB1	P50616	S152	PASSVSSSPSPPFGH
TOB1	P50616	S154	SSVSSSPSPPFGHSA
TOB1	P50616	S164	FGHSAAVSPTFMPRS
TOM1	O60784	S462	DRLPNLSSPSAEGPP
TOP2A	P11388	S1213	QMAEVLPSPRGQRVI
TOP2A	P11388	S1247	KNENTEGSPQEDGVE
TOP2A	P11388	S1354	DFVPSDASPPKTKTS
TOP2A	P11388	S1361	SPPKTKTSPKLSNKE
TOP2A	P11388	S1393	GSVPLSSSPPATHFP
TOP2B	Q02880	S1476	EDSASVFSPSFGLKQ
TP53BP1	Q12888	S380	TPFIVPSSPTEQEGR
TP53BP1	Q12888	T1056	RSEDPPTTPIRGNLL
TP53BP1	Q12888	T919	GDIIPPLTGATPPLI
TPI1	P60174	S117	GAFTGEISPGMIKDC
TPI1	P60174	T83	EVVCAPPTAYIDFAR
TPR	P12270	S2155	GFAEAIHSPQVAGVP
TPR	P12270	S2176	PEDMPQTSSSHSDLG
TPR	P12270	S652	PSTSQTVSTPAPVPV
TPR	P12270	T1677	KPTPVVSTPSKVTAA
TPR	P12270	T2137	EDRTVPSTPTLVVPH
TPR	P12270	T2196	GGLGMYETPLFLAHE
TPX2	Q9ULW0	S738	QPLTVPVSPKFSTRF
TPX2	Q9ULW0	T369	KICRDPQTPVLQTKH
TPX2	Q9ULW0	T734	KSSDQPLTVPVSPKF
TRIP6	Q15654	T158	GPTPASYTTASTPAG
TSC2	P49815	S664	KKTSGPLSPPTGPPG
TTK	P33981	S821	GQLVGLNSPNSILKA	?
TXLNG	Q9NUQ3	S97	TENRNLVSPAYCTQE
UBA1	P22314	S816	VSDQELQSANASVDD
UBA1	P22314	S835	ELKATLPSPDKLPGF
UBA1	P22314	T800	SVQVPEFTPKSGVKI
UBAP2L	Q14157	S416	PSDSAVHSPFTKRQA
UBAP2L	Q14157	S439	EVFLQEKSPAVATST
UBAP2L	Q14157	S454	AAPPPPSSPLPSKST
UBAP2L	Q14157	S475	PGSSDNQSSSPQPAQ
UBAP2L	Q14157	S859	SLASNPYSGDLTKFG
UBAP2L	Q14157	T425	FTKRQAFTPSSTMME
UBE2K	P61086	T49	EIAGPPDTPYEGGRY
UBF	P17480	T117	DFPKKPLTPYFRFFM	-
UBF	P17480	T201	DIPEKPKTPQQLWYT	-
UBQLN1	Q9UMX0	S285	DIQEPMLSAAQEQFG
UNG	P13051	S64	EPGTPPSSPLSAEQL
USP10	Q14694	S226	VSDIVPDSPFPGALG
USP10	Q14694	T74	PSDTLPRTPSYSISS
USP14	P54578	T235	SSSASAATPSKKKSL
USP15	Q9Y4E8	S229	RGPSTPKSPGASNFS
USP15	Q9Y4E8	T226	TWPRGPSTPKSPGAS
USP7	Q93009	S963	DELLECLSPATSRTF
UTP14A	Q9BVJ6	S571	LLTTQSPSVKSLAVP
VARS	P26640	S301	GPMPDSYSPRYVEAA
VGF	O15240	T185	QETAAAETETRTHTL
VIM	P08670	S419	SLPLPNFSSLNLRET
VIM	P08670	S56	SRSLYASSPGGVYAT
VIPR1	P32241	T438	STQVSMLTRVSPGAR
VIPR1	P32241	Y418	VLGWNPKYRHPSGGS
WAC	Q9BTA9	S265	ATPSTVPSSPFTLQS
WAPL	Q7Z5K2	S221	QFGKRPESPSEISPI
WAPL	Q7Z5K2	S226	PESPSEISPIKGSVR
WDR36	Q8NI36	S786	EPPKVPKSAPFFIPT
WDR44	Q5JSH3	S96	LSDQATASPIVARTD
WIBG	Q9BRP8	T72	PEATAPVTPSRPEGG
WIZ	O95785	S1012	KSPQLSLSPRPASPK
WIZ	O95785	S1146	KLPPPPGSPLGHSPT
WIZ	O95785	S1155	LGHSPTASPPPTARK
XDH	P47989	T1131	DTVSLSATGFYRTPN
XDH	P47989	Y1122	EDWVTAAYMDTVSLS
XRN2	Q9H0D6	T439	FTPSGILTPHALGSR
XTP3TPA	Q9H773	S85	EPGPQGWSPRERAAL
YAP1	P46937	S289	PPPLAPQSPQGGVMG
YAP1	P46937	S367	GTQNPVSSPGMSQEL
YAP1	P46937	T119	AGTAGALTPQHVRAH
YLPM1	P49750	S561	PRSSYLESPRGPRFD
YLPM1	P49750	S634	ITPSTSLSPRQSGPQ
ZC3H14	Q6PJT7	S515	VQPDKPASPKFIVTL
ZC3HC1	Q86WB0	S321	RLPLVPESPRRMMTR
ZC3HC1	Q86WB0	S370	RPEPEAASPTTRTRP
ZC3HC1	Q86WB0	T372	EPEAASPTTRTRPVT
ZCCHC8	Q6NZY4	T374	YPGFNISTPRGIPDE
ZFP91	Q96JP5	S101	QQPQAAKSPSPVQGK
Zinc finger protein 891	A8MT65	S526	IQCGKAFSQSSSLII
ZMYND8	Q9ULU4	T760	GSHSPPETPVLTRSS
ZNF280C	Q8ND82	S80	GIKSEPHSPGIPEIF
ZNF318	Q5VUA4	S2160	LELKTINSAGLGPSP
ZNF445	P59923	Y762	SHSKEEPYKCSQCGK
ZNF541	Q9H0D2	S798	KSKLTIFSRIQGGNI
ZNF541	Q9H0D2	Y806	RIQGGNIYRLPHPVK
ZNF768	Q9H5H4	S125	SPRYEPQSPGYEPRS
ZNF768	Q9H5H4	S83	SPRFEPESPGFESRS
ZNF768	Q9H5H4	S90	SPGFESRSPGLVPPS
ZNF768	Q9H5H4	S97	SPGLVPPSPEFAPRS
ZNF828	Q96JM3	S319	WKPGPPGSPRPWKSN
ZNF828	Q96JM3	S432	PLSPEIRSPAGSPEL
ZNF828	Q96JM3	S445	ELRKPSGSPDLWKLS
ZNF828	Q96JM3	T537	LFPEPAKTAPPASPE
ZYX	Q15942	S281	TPVASKFSPGAPGGS
ZYX	Q15942	S344	QNQNQVRSPGAPGPL
ZYX	Q15942	T179	YVPPPVATPFSSKSS
GORASP2	Q9H8Y8	T225	QMAGTPITPLKDGFT
4E-BP1	Q13541	S64	FLMECRNSPVTKTPP
4E-BP1	Q13541	S83	PTIPGVTSPSSDEPP
4E-BP1	Q13541	T45	PGGTLFSTTPGGTRI
4E-BP1	Q13541	T46	GGTLFSTTPGGTRII	?
4E-BP1	Q13541	T69	RNSPVTKTPPRDLPT
A6	Q12792	S143	KYLLSQSSPAPLTAA
AAK1	Q2M2I8	S623	VGSLTPPSSPKTQRA
AATF	Q9NY61	T146	SRSHSAKTPGFSVQS
ADAM17	P78536	T735	KPFPAPQTPGRLQPA
ADD1	P35611	S12	SRAAVVTSPPPTTAP
ADD3	Q9UEY8	S423	EDDTVPLSPLKYMAQ
ADPRHL2	Q9NX46	T64	SLEPDPGTPGSERTE
AEBP1	Q8IUX7	T1012	IDPSRPMTPQQRRLQ
AHNAK	Q09666	S3412	MPFLSISSPKVSMPD
AHNAK	Q09666	S3426	DVELNLKSPKVKGDL
AHNAK	Q09666	S5099	DVEFDIKSPKFKAEA
AHNAK	Q09666	S511	DVDLSLGSPKLKGDI
AHNAK	Q09666	S5763	EAEAEASSPKGKFSL
AHNAK	Q09666	S5793	EREFSGPSTPTGTLE
AHNAK	Q09666	T3716	GPKVDIDTPDINIEG
AHNAK	Q09666	T4430	GPSLDIDTPDVNIEG
AHNAK	Q09666	T4564	GPKVGIDTPDIDIHG
AHNAK	Q09666	T5184	GLDAKVKTPSFGISA
AKAP1	Q92667	S151	PLECPLSSPKGVLFS
AKAP12	Q02952	S283	EPSKSAESPTSPVTS
AKAP12	Q02952	S286	KSAESPTSPVTSETG
Akt1 (PKBa)	P31749	T308	KDGATMKTFCGTPEY	+
AKT1S1	Q96B36	S211	DEENGPPSSPDLDRI
ALDOA	P04075	Y343	SLACQGKYTPSGQAG
AML1 (RUNX1)	Q01196	S249	DTRQIQPSPPWSYDQ	+
AML1 (RUNX1)	Q01196	S266	QYLGSIASPSVHPAT
AML1 (RUNX1)	Q01196	S276	VHPATPISPGRASGM
AML1 (RUNX1)	Q01196	S435	AEGSHSNSPTNMAPS
AML1 (RUNX1)	Q01196	T273	SPSVHPATPISPGRA	+
AMPD2	Q01433	S142	LAESELRSAPYEFPE
Amphiphysin	P49418	S285	NHILAPASPAPARPR
Amphiphysin	P49418	S293	PAPARPRSPSQTRKG
ANK3	Q12955	S4298	GHVEEPASPLAAYQK
ANKHD1	Q8IWZ3	T2323	QGPAPVGTPSFNRQH
ANLN	Q9NQW6	T194	LLSNASATPVGRRGR
APRT	P07741	T21	RSFPDFPTPGVVFRD
AR	P10275	S515	VSRVPYPSPTCVKSE	-
AR	P10275	S650	GEASSTTSPTEETTQ	-
ARHGAP17	Q68EM7	T672	SLSPKPPTRSPSPPT
ARHGAP20	Q9P2F6	T38	SASVDTCTFLSSLVC
ARHGAP26	Q9UNA1	S685	PMFSAPSSPMPTSST
ARHGEF2	Q92974	S952	TGSEEEGSSRLSPPH
ARHGEF2	Q8TDA3	T679	PGVELLLTPREPALP	+
ARID1A	O14497	S357	SGGAQQRSHHAPMSP
ARID1B	Q8NFD5	S1559	NRMSPSKSPFLPSMK
ARID1B	Q8NFD5	S1869	SKSPFLPSMKMQKVM
ARRB1	P49407	S412	EEEDGTGSPQLNNR_
ATF2	P15336	T69	SVIVADQTPTPTRFL	+
ATF2	P15336	T71	IVADQTPTPTRFLKN	+
ATF7	P17544	T51	SVIIADQTPTPTRFL	-
ATF7	P17544	T53	IIADQTPTPTRFLKN	-
ATP1A1	P05023	S16	KYEPAAVSEQGDKKG
ATXN2L	Q8WWM7	S589	EVDGLLTSEPMGSPV
B-Raf	P15056	T753	YACASPKTPIQAGGY	-
BAG3	O95817	S283	REGSPARSSTPLHSP
BAG3	O95817	S289	RSSTPLHSPSPIRVH
BAG3	O95817	S377	PVPCPPPSPGPSAVP
BAG3	O95817	S385	PGPSAVPSSPKSVAT
BARK1 (GRK2, ADRBK1)	P25098	S670	KMKNKPRSPVVELSK	-
BAT2	P48634	S114	ESQPLPASQTPASNQ
BAT2	P48634	S1147	PPPGAPPSPAPARFT
BAT2	P48634	S1219	KLIPGPLSPVARGGS
BAT2	P48634	S516	AAPPAAPSTPAPPPA
BAT2	P48634	T132	PPAAPENTPLVPSGV
BAT2D1	Q9Y520	S2105	AQKLPDLSPVENKEH
BAT2D1	Q9Y520	T1980	ASGKSIQTPQSHGTL
BAT2D1	Q9Y520	T2673	GIDIKPGTPPIAGRS
BAT2D1	Q9Y520	T822	AEPQQATTPKATEEP
BAT3	P46379	S973	EPQRENASPAPGTTA
Bcl-2	P10415	S70	RDPVARTSPLQTPAA
Bcl-2	P10415	S87	AAAGPALSPVPPVVH	+
Bcl-2	P10415	T56	FSSQPGHTPHPAASR	+
Bcl-2	P10415	T74	ARTSPLQTPAAPGAA
Bcl-6	P41182	S333	KGLVSPQSPQKSDCQ
Bcl-6	P41182	S343	KSDCQPNSPTESCSS
BCLAF1	Q9NYF8	S228	NSPRSPHSPSPIATP
BCLAF1	Q9NYF8	Y839	EEEWDPEYTPKSKKY
BID	P55957	T59	EGYDELQTDGNRSSH	-
Bim	O43521	S104	FSFDTDRSPAPMSCD
Bim	O43521	S113	APMSCDKSTQTPSPP
Bim	O43521	S59	GDSCPHGSPQGPLAP
Bim	O43521	S69	GPLAPPASPGPFATR
Bim	O43521	T114	PMSCDKSTQTPSPPC
Bim iso2	O43521-2	T56	SCDKSTQTPSPPCQA
BLM	P54132	T114	LLPDFLQTPKEVVCT
BLVRA (BVA)	P53004	S230	LKRNRYLSFHFKSGS
BMAL1	O00327	T484	SPLNITSTPPPDASS
BRD4	O60885	S1126	IIRSEPFSPSLRPEP
BRD8	Q9H0E9-2	S268	QkATPPPSPLLSELL
BRD8	Q9H0E9-2	T283	KKGSLLPTSPRLVNE
BSDC1	Q9NW68	S235	LMGISPISPKEAKVP
BTG2	P78543	S147	QVLLGRSSPSKNYVM
C-EBPa	P49715	S21	PMSSHLQSPPHAPSS
C-EBPb	P17676	T235	SSSSPPGTPSPADAK
C12orf45	Q8N5I9	S66	QTVRIERSPLLDQVQ
C14orf142	Q9BXV9	S35	DPFQGLLSGVAQMKD
C15orf44	Q96SY0	S387	YGEDDNKSPFPLQPK
C2orf49	Q9BVC5	S193	PVKSPPLSPVGTTPV
C2orf49	Q9BVC5	T197	PPLSPVGTTPVKLKR
C6orf108	O43598	S169	PPGQVAASPDPTT__
CA2	P00918	S29	IAKGERQSPVDIDTH
CACNA1B	Q00975	S411	DRNAEEKSPLDVLKR
CACNA1B	Q00975	S446	ADLCAVGSPFARASL
CACNB1	Q02641	S161	CEVGFIPSPVKLDSL
CACNB1	Q02641	S348	IVYIKITSPKVLQRL
CAD	P27708	T456	KVYFLPITPHYVTQV
CALD1	Q05682	S691	SAIEGTKSAKPTKPA
CALD1	Q05682	S759	KTPDGNKSPAPKPSD	?
CALD1	Q05682	S789	QSVDKVTSPTKV___
Calpain 2	P17655	S49	GTLFQDPSFPAIPSA	+
CALU	O43852	T65	AKTFDQLTPEESKER
CAPZB	P47756	S90	LEDGAMPSARLRKLE
CaRHSP1	Q9Y2V2	S41	LRGNVVPSPLPTRRT
Caspase 9	P55211	T125	PEVLRPETPRPVDIG
CASZ1	Q86V15	T272	VGKEVVGTLPGLRLP
CBR1	P16152	S56	QLQAEGLSPRFHQLD
CBX8	Q9HC52	S352	DPEEESWSPSLTNLE
CCDC102B	Q68D86	S22	IFQMQQSSIKSRGDM
CCDC6	Q16204	S240	EKLDQPVSAPPSPRD
CCDC6	Q16204	S244	QPVSAPPSPRDISME
CCDC86	Q9H6F5	S47	EETREPGSPPSVQRA
CCDC86	Q9H6F5	S80	QQGAGLESPQGQPEP
CCDC88C	Q9P219	S233	PSPIKSSSADSTPSP
CCDC97	Q96F63	S212	HQPPKPGSPGRPACP
CD276	Q5ZPR3	T244	ITPQRSPTGAVEVQV
CD3EAP	O15446	S136	PLQPIPASPPPQIPP
Cdc27	P30260	T366	TPQVLSPTITSPPNA
CDC42EP4	Q9H3Q1	S174	NGAAGPHSPDPLLDE
CDC42EP4	Q9H3Q1	S322	SGILEERSPAFRGPD
CDC5L	Q99459	S277	KKESDLPSAILQTSG
CDC5L	Q99459	S410	QTPNTVLSTPFRTPS
CDC5L	Q99459	T385	PLKGGLNTPLHESDF
CDC5L	Q99459	T404	PQRQVVQTPNTVLST
CDCA3	Q99618	T37	PSAGILRTPIQVESS
CDCA5	Q96FF9	S154	SRLETLGSASTSTPG
CDCA5	Q96FF9	S158	TLGSASTSTPGRRSC
CDCA5	Q96FF9	S75	VEVPAVQSPRRSPRI
CdGAP	Q9ULL6	T790	PPAPPPPTPLEESTP
CDH2	P19022	S824	EPQYPVRSAAPHPGD
CDK2	P24941	T160	GVPVRTYTHEVVTLW	+
CENPC1	Q03188	S177	SQNVIPSSAKKRETY
CEP170	Q5SW79	T174	ISAMPRGTPLYGQPS
CFDP1	Q9UEE9	S207	KPQANVPSALPSLPA
CHAF1A	Q13111	S294	LSSPSSTSSPEGPPA
CHAF1B	Q13112	S458	SITPAVKSPLPGPSE
CIC	Q96RK0	S1373	RPEEVLPSPTLQSLA
CIITA	P33076	S280	TVHGLPTSPDRPGST
CIITA	P33076	S288	PDRPGSTSPFAPSAT
CKB	P12277	S199	FLFDKPVSPLLLASG
CKB	P12277	T35	NHMAKVLTPELYAEL
CLCC1	Q96S66	S438	RFQTGNKSPEVLRAF
CLIC1	O00299	Y143	ALKVLDNYLTSPLPE
CLIM1	O00151	S90	RSEHKVWSPLVTEEG
CLIM1	O00151	T128	NRSAMPFTASPASST
CLINT1	Q14677	S182	RYDPEPKSKWDEEWD
CLIP1	P30622	T25	PGSTALKTPTAVVAP
CLTA	P09496	S206	VNDIDESSPGTEWER
CNOT3	O75175	S507	LPVNPPSSPTPSFSD
COBRA1	Q8WX92	T564	SPAQAAETPALELPL
Cortactin	Q14247	S418	TEERLPSSPVYEDAA
cPLA2	P47712	S505	LNTSYPLSPLSDFAT	+
CPSF7	Q8N684	S212	SENLVPSSARVDKPP
CRTC2	Q53ET0	S623	NIILTGDSSPGFSKE
CRTC2	Q53ET0	T497	SPSLVLPTQPHTPKS
CRTC2	Q53ET0	Y486	TDQRLPPYPYSSPSL
CRYAB	P02511	S45	FPTSTSLSPFYLRPP
CRYAB	P02511	S59	PSFLRAPSWFDTGLS	?
CSTF2	P33240	T317	SLPANVPTPRGLLGD
CTPS	P17812	S575	SDRSGSSSPDSEITE
CTTN (Cortactin)	Q14247	S135	QMDRVDQSAVGFEYQ
CTTN (Cortactin)	Q14247	S172	QADRVDKSAVGFDYQ
CTTN (Cortactin)	Q14247	S332	EDVTQVSSAYQKTVP
CTTN (Cortactin)	Q14247	S405	KTQTPPVSPAPQPTE	-
CTTN (Cortactin)	Q14247	S418	TEERLPSSPVYEDAA	?
CTTN (Cortactin)	Q14247	T401	QARAKTQTPPVSPAP
CTTNBP2NL	Q9P2B4	S568	PLSPGIKSPTIPRAE
Cx43	P17302	S254	HATSGALSPAKDCGS
Cx43	P17302	S278	SSPTAPLSPMSPPGY
Cx43	P17302	S281	TAPLSPMSPPGYKLV
DAT (Dopamine transporter)	Q01959	S53	TLTNPRQSPVEAQDR
DBN1	Q16643	S312	AGSCDVPSPFNHRPG
DBN1	Q16643	T331	SHRRMAPTPIPTRSP
DBN1	Q16643	T346	SDSSTASTPVAEQIE
DCP1A	Q9NPI6	S315	PTYTIPLSPVLSPTL
DCP1A	Q9NPI6	S319	IPLSPVLSPTLPAEA
DDX17	Q92841	S64	PEPQALPSSPAIRAP
DDX19A	Q9NUU7	S85	VLQRDPNSPLYSVKS
DENND4C	Q5VZ89	S737	QPSPEPHSPTEPPAW
DHX38	Q92620	T117	YRSARVETPSHPGGV
DLAT	P10515	S100	KVPLPSLSPTMQAGT
DLG4 (PSD-95)	P78352	S290	PTAMTPTSPRRYSPV
DLG4 (PSD-95)	P78352	T287	TDYPTAMTPTSPRRY
DLGAP5	Q15398	S332	VTPMTPRSANAFLTP
DPYSL3	Q14195-2	S102	SREPAPASPAPAGVE
DSCR1	P53805	S112	FLISPPASPPVGWKQ
DSN1	Q9H410	S30	HQLESSLSPVEVFAK
DUSP1 (MPK1)	P28562	S296	KQRRSIISPNFSFMG	-
DUSP1 (MPK1)	P28562	S323	HCSAEAGSPAMAVLD	-
DYNC1H1	Q14204	S2410	DEGEEAASPMLQIQR
DYNC1LI1	Q9Y6G9	S516	VSPTTPTSPTEGEAS
EEF1B2	P24534	S43	AVFEAVSSPPPADLC
EEF1B2	P24534	S8	MGFGDLKSPAGLQVL
EEF2	P13639	T779	EESQVAGTPMFVVKA
EFHD2	Q96C19	S74	QGIGEPQSPSRRVFN
EFTUD2	Q15029	T870	IPGSPLYTIKAFIPA
EGFR	P00533	T693	RELVEPLTPSGEAPN	-
EIF2A	Q9BY44	T512	KSPDLAPTPAPQSTP
eIF4B	P23588	S93	DRSRLPKSPPYTAFL
eIF4B	P23588	T97	LPKSPPYTAFLGNLP
eIF4B	P23588	Y96	RLPKSPPYTAFLGNL
EIF4G1	Q04637	S1067	EAALPPVSPLKAALS
EIF4G1	Q04637	S198	DITEEIMSGARTAST
EIF4G1	Q04637	T207	ARTASTPTPPQTGGG
EIF4G3	O43432	S160	DITEEIMSGGGSRNP
EIF4H	Q15056	S230	NQVANPNSAIFGGAR
EIF4H	Q15056	T220	LKPRTVATPLNQVAN
Elk-1	P19419	S324	RDLELPLSPSLLGGP	+
Elk-1	P19419	S383	IHFWSTLSPIAPRSP	+
Elk-1	P19419	S389	LSPIAPRSPAKLSFQ	+
Elk-1	P19419	S422	LSTPVVLSPGPQKP_	+
Elk-1	P19419	T336	GGPGPERTPGSGSGS
Elk-1	P19419	T353	QAPGPALTPSLLPTH	+
Elk-1	P19419	T363	LLPTHTLTPVLLTPS	+
Elk-1	P19419	T368	TLTPVLLTPSSLPPS	+
Elk-1	P19419	T417	ISVDGLSTPVVLSPG	+
ENaC beta	P51168	T615	QALPIPGTPPPNYDS
ENaC gamma	P51170	T622	LGTQVPGTPPPKYNT
Endofin	Q7Z3T8	S939	TRNEIIQSPISQVPS
ENO1	P06733	S263	KYDLDFKSPDDPSRY
ENO1	P06733	T229	EGLELLKTAIGKAGY
ENSA	O43768	T99	VTGDHIPTPQDLPQR
EPN1	Q9Y6I3	S395	ALPTSGSSAGELELL
EPN2	O95208	S343	DLMDALPSSGPAAQK
EPS15	P42566	S662	SDCFFRQSTDPFATS
ERa (ESR1)	P03372	S104	FPPLNSVSPSPLMLL	+
ERa (ESR1)	P03372	S106	PLNSVSPSPLMLLHP	+
ERa (ESR1)	P03372	S118	LHPPPQLSPFLQPHG	+
ERb (ESR2)	Q92731	S105	LYAEPQKSPWCEARS
ERb (ESR2)	Q92731	S87	WPTPGHLSPLVVHRQ	+
ERCC6L	Q2NKX8	S755	NKPQPQPSPLLSTHH
ERF	P50548	T526	GEAGGPLTPRRVSSD
ERK1 (MAPK3)	P27361	T17	GGGEPRRTEGVGPGV
ERK1 (MAPK3)	P27361	T198	ADPEHDHTGFLTEYV	?
ERK1 (MAPK3)	P27361	T202	HDHTGFLTEYVATRW	+
ERK1 (MAPK3)	P27361	T207	FLTEYVATRWYRAPE	-
ERK1 (MAPK3)	P27361	T368	KELIFQETARFQPGV
ERK1 (MAPK3)	P27361	Y204	HTGFLTEYVATRWYR	+
ERO1L	Q96HE7	S115	EVPDGIKSASYKYSE
Ets-1	P14921	T38	CADVPLLTPSSKEMM	+
Ets-2	P15036	T72	NCELPLLTPCSKAVM	+
ETV1 (ER81)	P50549	S146	TPSSTPVSPLHHASP
ETV1 (ER81)	P50549	S94	KIKKEPHSPCSEISS
ETV6	P41212	S213	DNMIRRLSPAERAQG	-
ETV6	P41212	S257	ESHPKPSSPRQESTR	-
EWS	Q01844	T422	VSYEDPPTAKAAVEW
EWS	Q01844	T79	QPPTGYTTPTAPQAY
FAK (PTK2)	Q05397	S910	KLQPQEISPPPTANL	?
FAM122A	Q96E09	S143	RIDFIPVSPAPSPTR
FAM122A	Q96E09	S147	IPVSPAPSPTRGIGK
FAM122A	Q96E09	S276	VSPAQAASPFIPLDE
FAM122A	Q96E09	S76	HGLLLPASPVRMHSS
FAM122B	Q7Z309	S115	RIDFTPVSPAPSPTR
FAM122B	Q7Z309	S119	TPVSPAPSPTRGFGK
FAM21A	Q641Q2	S1114	PVPGVDRSPFAKSLG
FAM21D	Q5SRD0	T80	GPVPGVDTSPFAKSL
FASN	P49327	S831	PRGTPLISPLIKWDH
FASN	P49327	T827	PRGTPLISPLISPLI

Protein Kinase Specificity

Matrix of observed frequency (%) of amino acids in aligned protein substrate phosphosites

Matrix Type:

Experimentally derived from alignment of 389 known protein substrate phosphosites. Note that additional binding sites on ERK1 substrates with D motifs (consensus=L-x-e-R/k-R/k-x-x-x-x-x-l/i/v-p-p or p-x-L/v/i-x-p-p-x-x-x-x-l-l-x-r/k-k/r-R/k-K/r) and/or FxFP motifs (Phe-any amino acid-Phe-Pro) facilitate higher selectivity for phosphorylation by this protein kinase.

Domain #:

Inhibitors

For further details on these inhibitors click on the Compound Name and enter it into DrugKiNET or click on the ID's

Based on in vitro and/or in vivo phosphorylation data

Compound Name	KD, Ki or IC50 (nM)	PubChem ID	ChEMBL ID	PubMed ID

Staurosporine	IC50 = 1 nM	5279		12166950
CHEMBL387385	Ki = 2 nM	16115004	387385	17300186
Hymenialdisine	IC50 = 6 nM	3035462		15261294
TTT-3002	IC50 < 8 nM
Aminopurvalanol A	IC50 = 12 nM	6604931		12678910
CHEMBL1092754	IC50 = 50 nM	44541014	1092754	20188552
PKR Inhibitor	IC50 > 50 nM	6490494	235641	22037377
Staurosporine aglycone	IC50 < 60 nM	3035817	281948
GDC0879	IC50 = 63 nM	11717001	525191	18676143
7-hydroxystaurosporine	IC50 > 100 nM	72271	1236539
A 443654	IC50 = 100 nM	10172943	379300
AT9283	IC50 > 100 nM	24905142		19143567
Gö6976	IC50 = 100 nM	3501	302449
IPA-3	IC50 < 100 nM	521106	472940
K-252a; Nocardiopsis sp.	IC50 > 150 nM	3813	281948	22037377
A674563	Ki = 260 nM	11314340	379218	16678413
CHEMBL195641	IC50 = 300 nM	44401410	195641	15808450
FR180204	Ki = 310 nM	11493598	259551	18077363
CHEMBL213618	IC50 = 400 nM	16043304	213618	16765046
NVP-TAE684	Kd = 430 nM	16038120	509032	22037378
Syk Inhibitor IV	IC50 < 600 nM	10200390
CHEMBL364935	IC50 = 750 nM	44401506	364935	15808450
Novartis 12a (PKD1)	IC50 < 800 nM
Debromohymenialdisine	IC50 = 824 nM	5288032		11784156
BX517	IC50 > 900 nM	11161844	228654
AC1OCAB6	IC50 = 910 nM	6914611	383264	16413780
Baricitinib	IC50 > 1 µM	44205240		20363976
BX795	IC50 = 1 µM	10077147	577784
Cdk1/2 Inhibitor III	IC50 = 1 µM	5330812	261720	15974571
CHEMBL194721	IC50 > 1 µM	44401437	194721	15808450
Hypothemycin	IC50 = 1 µM	5477775	471474
ML3403	IC50 > 1 µM	6419739	111364	22037377
Regorafenib	IC50 > 1 µM	11167602		21170960
Silmitasertib	IC50 > 1 µM	24748573		21174434
SNS314	IC50 > 1 µM	16047143	514582	18678489
SureCN3470757	IC50 = 1 µM	11588244	375236
Tozasertib	IC50 < 1 µM	5494449	572878	17850214
WZ3146	Kd > 1 µM	44607360		20033049
WZ4002	Kd > 1 µM	44607530		20033049
BCP9000906	IC50 = 1.78 µM	5494425	21156	11934592
Momelotinib	IC50 > 2 µM	25062766		19295546
SureCN10063060	Ki > 2 µM	52936621		21391610
Pyrrolo-pyrimidone; 17	IC50 = 2.6 µM	16119021	461140	18945615
AC1NS3UT	IC50 = 2.8 µM	5328135	45827	11384237
PD98059	IC50 = 2.8 µM	4713	35482	11784156
(5Z)-7-Oxozeaenol	IC50 > 3 µM		1077979
Purvalanol B	IC50 > 3 µM	448991	23254
Kinome_3027	Ki = 3.9 µM	11640926	378627	16759099
EGCG (Epigallocatechin Gallate)	IC50 < 4 µM	65064	297453
JNJ-28871063	IC50 > 4 µM	17747413		17975007
KT5720	IC50 > 4.5 µM	3844	608532
R406	IC50 > 4.5 µM	11984591
JNK Inhibitor VIII	Ki = 4.7 µM	11624601	210618	16759099

Disease Linkage

General Disease Association:

Cancer, neurological disorders

Specific Diseases (Non-cancerous):

Corticobasal degeneration

Comments:

Corticobasal degeneration is a neurological disease characterized by the progressive degeneration of multiple regions of the cerebral cortex and basal ganglia. Symptoms of the disease are similar to those of Parkinson's disease (PD), including poor motor coordination, hypokinesia, balance problems, abnormal muscular postures, cognitive impairment, hesitant and halting speech, and apraxia. ERK1-deficient mice were observed to demonstrate an enhanced striatum-dependent (striatum = caudate nucleus and putamen, parts of the basal ganglia) long-term memory along with changes in the nucleus accumbens. ERK1 has a critical regulatory role in adaptive changes in the basal ganglia. This is in agreement with the observation that plasticity in the developing rat visual cortex involves ERK1 activation. Thus, ERK1 is implicated in the regulation of plasticity in the central nervous system. In addition, ERK1 activation has been implicated as an important mediator of neuronal death in neurodegenerative diseases, including corticobasal degeneration, through a caspase-3-independent mechanism. Therefore, abnormal activity or expression of the ERK1 protein may have a role in the pathogenesis of corticobasal degeneration.

Specific Cancer Types:

Breast cancer; Familial medullary thyroid carcinomas; Pleomorphic rhabdomyosarcoma

Comments:

ERK1 appears to be a tumour requiring protein (TRP). The active form of the protein kinase normally acts to promote tumour cell proliferation. Abnormal functioning of the MAPK3 protein has been associated with several types of human cancer. In addition, over activation of the MAP kinase signalling pathway is involved in the malignant transformation of cancer cells, as demonstrated both in vivo and in vitro. Mutations resulting in the activation of the MAPK3 protein, but not necessary the over-expression of the MAPK3 protein, have been associated with tumorigenesis in several cancer types.

Gene Expression in Cancers:

TranscriptoNET (www.transcriptonet.ca) analysis with mRNA expression data retrieved from the National Center for Biotechnology Information's Gene Expression Omnibus (GEO) database, which was normalized against 60 abundantly and commonly found proteins, indicated altered expression for this protein kinase as shown here as the percent change from normal tissue controls (%CFC) as supported with the Student T-test in the following types of human cancers: Barrett's esophagus epithelial metaplasia (%CFC= -46, p<0.017); Cervical epithelial cancer (%CFC= +52, p<0.036); Malignant pleural mesotheliomas (MPM) tumours (%CFC= +101, p<0.03); Prostate cancer (%CFC= +116, p<0.011); Skin melanomas - malignant (%CFC= +52, p<0.023); T-cell prolymphocytic leukemia (%CFC= +109, p<0.072); and Uterine fibroids (%CFC= +70, p<0.036).

Mutagenesis Experiments:

Insertional mutagenesis studies in mice support a role for this protein kinase in mouse cancer oncogenesis.

Mutation Rate in All Cancers:

Percent mutation rates per 100 amino acids length in human cancers: 0.06 % in 24447 diverse cancer specimens. This rate is only -17 % lower than the average rate of 0.075 % calculated for human protein kinases in general.

Mutation Rate in Specific Cancers:

Highest percent mutation rates per 100 amino acids length in human cancers: 0.49 % in 805 skin cancers tested.

Frequency of Mutated Sites:

None > 2 in 20,654 cancer specimens

Comments:

No deletions, insertions or complex mutations are noted on the COSMIC website.

COSMIC Entry:

MAPK3

OMIM Entry:

601795

Nomenclature

Short Name:

Full Name:

Alias:

Classification

Type:

Group:

Family:

SubFamily:

Specific Links

General Links

Structure

Mol. Mass (Da):

# Amino Acids:

# mRNA Isoforms:

mRNA Isoforms:

4D Structure:

1D Structure:

3D Image (rendered using PV Viewer):

PDB ID

Subfamily Alignment

Domain Distribution:

Kinexus Products

hiddentext

Post-translation Modifications

Acetylated:

Serine phosphorylated:

Threonine phosphorylated:

Tyrosine phosphorylated:

Ubiquitinated:

Distribution

Human Tissue Distribution

% Max Expression: Mean Expression: Number of Samples: Standard Deviation:

% Max Expression: Mean Expression: Number of Samples: Standard Deviation:

Evolution

Species Conservation

PhosphoNET % Identity: PhosphoNET % Similarity: Homologene %Identity:

PhosphoNET % Identity: PhosphoNET % Similarity: Homologene %Identity:

Binding Proteins

hiddentext

Regulation

Activation:

Inhibition:

Synthesis:

Degradation:

Kinections Map

Known Upstream Kinases

Based on in vitro and/or in vivo phosphorylation data

Known Downstream Substrates

Based on in vitro and/or in vivo phosphorylation data

Protein Kinase Specificity

Matrix Type:

Domain #:

Inhibitors

Based on in vitro and/or in vivo phosphorylation data

Disease Linkage

General Disease Association:

Specific Diseases (Non-cancerous):

Comments:

Specific Cancer Types:

Comments:

Gene Expression in Cancers:

Mutagenesis Experiments:

Mutation Rate in All Cancers:

Mutation Rate in Specific Cancers:

Frequency of Mutated Sites:

Comments:

COSMIC Entry:

OMIM Entry:

% Max Expression:

Mean Expression:

Number of Samples:

Standard Deviation:

% Max Expression:

Mean Expression:

Number of Samples:

Standard Deviation:

PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:

PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity: