KinaseNET

Nomenclature

Short Name:

p70S6K

Full Name:

Ribosomal protein S6 kinase 1

Alias:

EC 2.7.11.1
KS6B1
S6K
S6K1
STK14A
p70-alpha
p70(S6K)-alpha
Ribosomal protein S6 kinase I
RPS6KB1

Classification

Type:

Protein-serine/threonine kinase

Group:

AGC

Family:

RSK

SubFamily:

p70

Specific Links

BioCarta Entry:	eif4 pathway
Entrez-Gene Entry:	6198
Entrez-Protein Entry:	NP_003152
GeneCards Entry:	S6K1
KinBASE Entry:	P70S6K
OMIM Entry:	608938
Pfam Entry:	P23443
PhosphoNET Entry:	P23443
Phosphosite Plus Entry:	628
ScanSite Entry:	P23443
Source Entry:	RPS6KB1
UCSD-Nature Entry:	A000530
UniProt Entry:	P23443
Kinexus Products:	p70S6K Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase 1 pan-specific antibody AB-NK168-NK169-2 Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase 1 pan-specific antibody AB-NK223-2 Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase 1 pan-specific antibody AB-NK223-4 Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase 1 T252 phosphosite-specific antibody AB-PK744 Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase 1 T412 phosphosite-specific antibody AB-PK745 Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase 1 T444+S447 phosphosite-specific antibody AB-PK746 GSK3b (3-12) KinSub - Glycogen synthase kinase 3-beta (GSK3b) N-terminus (G3-E12, human) peptide; Akt protein kinase substrate peptide - Powder PE-01ACT95 RPS6 (230-238) KinSub - 40S ribosomal protein S6 (K230-R238, human) peptide; p70S6K protein kinase substrate peptide - Powder PE-01ADQ95 Ribosomal protein S6 kinase beta-1 / Ribosomal protein S6 kinase 1 (A128-P153, human) peptide - Powder PE-01AQP75 S6KASubtide - p70S6K (RPS6KB1) protein kinase substrate peptide - Powder PE-01BJH95 Ribosomal protein S6 kinase beta-1 / Ribosomal protein S6 kinase 1 (P442-K449, human) pT444+pS447 phosphopeptide - Powder PE-04AGG95 Ribosomal protein S6 kinase beta-1 / Ribosomal protein S6 kinase 1 (L409-A415, human) pT412 phosphopeptide - Powder PE-04AGH85 Ribosomal protein S6 kinase beta-1 / Ribosomal protein S6 kinase 1 (V249-G255, human) pT252 phosphopeptide - Powder PE-04AKT99

General Links

Structure

Mol. Mass (Da):

59,140

# Amino Acids:

525

# mRNA Isoforms:

mRNA Isoforms:

59,140 Da (525 AA; P23443); 56,593 Da (502 AA; P23443-4); 56,189 Da (502 AA; P23443-2); 52,997 Da (472 AA; P23443-3); 51,016 Da (451 AA; P23443-5)

4D Structure:

Interacts with PPP1R9A/neurabin-1 By similarity. Interacts with RPTOR. Interacts with IRS1. Interacts with EIF3B and EIF3C. Interacts with POLDIP3.

1D Structure:

Retrieve Gene Sequence
Retrieve Full Protein Sequence
Retrieve Catalytic Domain Sequence

3D Image (rendered using PV Viewer):

PDB ID

3A62

Subfamily Alignment

Domain Distribution:

Start	End	Domain
91	352	Pkinase
353	423	Pkinase_C

Kinexus Products

Click on entries below for direct links to relevant products from Kinexus for this protein kinase.

hiddentext

○	Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase 1 pan-specific antibody AB-NK168-NK169-2
○	Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase 1 pan-specific antibody AB-NK223-2
○	Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase 1 pan-specific antibody AB-NK223-4
○	Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase 1 T252 phosphosite-specific antibody AB-PK744
○	Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase 1 T412 phosphosite-specific antibody AB-PK745
○	Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase 1 T444+S447 phosphosite-specific antibody AB-PK746
○	GSK3b (3-12) KinSub - Glycogen synthase kinase 3-beta (GSK3b) N-terminus (G3-E12, human) peptide; Akt protein kinase substrate peptide - Powder PE-01ACT95
○	RPS6 (230-238) KinSub - 40S ribosomal protein S6 (K230-R238, human) peptide; p70S6K protein kinase substrate peptide - Powder PE-01ADQ95
○	Ribosomal protein S6 kinase beta-1 / Ribosomal protein S6 kinase 1 (A128-P153, human) peptide - Powder PE-01AQP75
○	S6KASubtide - p70S6K (RPS6KB1) protein kinase substrate peptide - Powder PE-01BJH95
○	Ribosomal protein S6 kinase beta-1 / Ribosomal protein S6 kinase 1 (P442-K449, human) pT444+pS447 phosphopeptide - Powder PE-04AGG95
○	Ribosomal protein S6 kinase beta-1 / Ribosomal protein S6 kinase 1 (L409-A415, human) pT412 phosphopeptide - Powder PE-04AGH85
○	Ribosomal protein S6 kinase beta-1 / Ribosomal protein S6 kinase 1 (V249-G255, human) pT252 phosphopeptide - Powder PE-04AKT99

Post-translation Modifications

For detailed information on phosphorylation of this kinase go to PhosphoNET

Acetylated:

K304, K516.

Serine phosphorylated:

S40+, S53, S243, S375, S380, S394+, S403, S417, S421, S427+, S434+, S441+, S447+, S452.

Threonine phosphorylated:

T248+, T250+, T252+, T256+, T390, T412+, T444+, T470.

Tyrosine phosphorylated:

Y62, Y413.

Distribution

Based on gene microarray analysis from the NCBI

Human Tissue Distribution

% Max Expression:

Mean Expression:

Number of Samples:

Standard Deviation:

29

975

35

997
1

32

24

28
5

157

16

196
13

443

138

968
23

785

41

687
2

76

90

96
9

302

55

461
34

1147

65

2480
10

331

23

356
3

103

143

102
2

70

52

93
13

446

239

562
3

104

38

162
1.3

42

23

40
2

76

32

113
2

64

22

48
1.4

48

390

173
3

86

32

110
3

110

140

124
22

737

143

731
3

86

47

136
3

101

48

146
4

120

26

116
2

70

34

109
3

101

47

156
21

695

94

1125
3

84

47

95
4

122

31

217
3

100

34

143
2

72

42

71
29

969

24

911
100

3344

41

7153
28

948

118

1322
25

825

83

710
4

126

48

166

Evolution

Species Conservation

PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:

100

100

100
85.9

85.9

100
94.3

95.6

-
-

-

100
-

-

99
99.8

100

100
-

-

-
99.2

99.4

99
99.6

99.6

99
-

-

-
90.3

90.9

-
31.9

46.7

97
36.9

52.8

92.5
32.3

46.6

86
-

-

-
20.9

31.4

73
54.7

68

-
31.3

43.6

68
59

70.9

-
-

-

-
-

-

-
-

-

49
36.4

55

49
-

-

-
-

-

-

For a wider analysis go to PhosphoNET Evolution in PhosphoNET

Binding Proteins

Examples of known interacting proteins

hiddentext

No.	Name – UniProt ID
1	RPTOR - Q8N122
2	DOCK5 - Q9H7D0
3	MAPT - P10636
4	NCBP1 - Q09161
5	PDPK2 - Q6A1A2
6	PDPK1 - O15530
7	AKT1 - P31749
8	RPS6 - P62753
9	EEF2K - O00418
10	EIF3B - P55884
11	PPP1R9B - Q96SB3
12	ACTA1 - P68133
13	NEK6 - Q9HC98
14	CDC2 - P06493
15	PDK1 - Q15118

Regulation

Activation:

Phosphorylation at Thr-252, Ser-394, Thr-412, Ser-427, Ser-434, Ser-441, Thr-444 and Ser-447 increases phosphotransferase activity.

Inhibition:

Synthesis:

Degradation:

Known Upstream Kinases

For further details on these substrates click on the Substrate Short Name or UniProt ID. Phosphosite Location is hyperlinked to PhosphoNET predictions.

Based on in vitro and/or in vivo phosphorylation data

Kinase Short Name	UniProt ID (Human)	Phosphosite Location	Phosphosite Sequence	Effect of Phosphorylation

CK2a1	P68400	S40	DQPEDAGSEDELEEG	+
SRC	P12931	Y62	DHGGVGPYELGMEHC
SRC	P12931	T250	SIHDGTVTHTFCGTI	+
PDK1	O15530	T252	HDGTVTHTFCGTIEY	+
PIK3CD	O00329	T252	HDGTVTHTFCGTIEY	+
SRC	P12931	S375	PFKPLLQSEEDVSQF
SRC	P12931	S380	LQSEEDVSQFDSKFT
CDK1	P06493	S394	TRQTPVDSPDDSTLS	+
FRAP1	P42345	S394	TRQTPVDSPDDSTLS	+
FRAP1	P42345	T412	NQVFLGFTYVAPSVL	+
p70S6K	P23443	T412	NQVFLGFTYVAPSVL	+
PDK1	O15530	T412	NQVFLGFTYVAPSVL	+
PIK3CD	O00329	T412	NQVFLGFTYVAPSVL	+
NEK6	Q9HC98	T412	NQVFLGFTYVAPSVL	+
JNK1	P45983	S434	SFEPKIRSPRRFIGS	+
ERK2	P28482	S434	SFEPKIRSPRRFIGS	+
CDK5	Q00535	S434	SFEPKIRSPRRFIGS	+
JNK2	P45984	S434	SFEPKIRSPRRFIGS	+
CDK1	P06493	S434	SFEPKIRSPRRFIGS	+
FRAP1	P42345	S434	SFEPKIRSPRRFIGS	+
ERK1	P27361	S434	SFEPKIRSPRRFIGS	+
CDK1	P06493	S441	SPRRFIGSPRTPVSP	+
ERK2	P28482	T444	RFIGSPRTPVSPVKF	+
CDK1	P06493	T444	RFIGSPRTPVSPVKF	+
ERK1	P27361	T444	RFIGSPRTPVSPVKF	+
CDK5	Q00535	S447	GSPRTPVSPVKFSPG	+
ERK2	P28482	S447	GSPRTPVSPVKFSPG	+
CDK1	P06493	S447	GSPRTPVSPVKFSPG	+
ERK1	P27361	S447	GSPRTPVSPVKFSPG	+

Known Downstream Substrates

For further details on these substrates click on the Substrate Short Name or UniProt ID. Phosphosite Location is hyperlinked to PhosphoNET predictions.

Based on in vitro and/or in vivo phosphorylation data

Substrate Short Name	UniProt ID (Human)	Phosphosite Location	Phosphosite Sequence	Effect of Phosphorylation

BACH2	Q9BYV9	S521	ETRTRTSSSCSSYSY
Bad	Q92934	S99	PFRGRSRSAPPNLWA	-
CCT2	P78371	S260	GSRVRVDSTAKVAEI
CREM	Q03060-2	S71	EILSRRPSYRKILNE
eEF2K	O00418	S366	SPRVRTLSGSRPPLL	-
eIF4B	P23588	S422	RERSRTGSESSQTGT
ERa (ESR1)	P03372	S167	GGRERLASTNDKGSM	?
FRAP1 (mTOR)	P42345	S2448	RSRTRTDSYSAGQSV	+
FRAP1 (mTOR)	P42345	T2446	NKRSRTRTDSYSAGQ	-
GluR1	P42261	T858	NEAIRTSTLPRNSGA
GSK3b	P49841	S9	SGRPRTTSFAESCKP	-
IRS1	P35568	S1101	GCRRRHSSETFSSTP	-
IRS1	P35568	S270	EFRPRSKSQSSSNCS
IRS1	P35568	S307	TRRSRTESITATSPA	-
IRS1	P35568	S312	TESITATSPASMVGG	-
IRS1	P35568	S527	RFRKRTHSAGTSPTI	?
IRS1	P35568	S616	DDGYMPMSPGVAPVP	-
IRS1	P35568	S636	SGDYMPMSPKSVSAP	-
IRS1	P35568	S639	YMPMSPKSVSAPQQI	-
LKB1 (STK11)	Q15831	S428	SSKIRRLSACKQQ__	+
Mad1 (MXD1)	Q05195	S145	IERIRMDSIGSTVSS	-
NDRG2	Q9UN36	S332	LSRSRTASLTSAASV
NDRG2	Q9UN36	S350	RSRSRTLSQSSESGT
p63	Q9H3D4	S560	LARLGCSSCLDYFTT	-
p70S6K (RPS6KB1)	P23443	T412	NQVFLGFTYVAPSVL	+
PDCD4	Q53EL6	S67	KRRLRKNSSRDSGRG
PFKFB2	O60825	S466	PVRMRRNSFTPLSSS
PFKFB2	O60825	S483	IRRPRNYSVGSRPLK
POLDIP3	Q9BY77	S383	ELPRRVNSASSSNPP
POLDIP3	Q9BY77	S385	PRRVNSASSSNPPAE
RSK1 (RPS6KA1)	Q15418	S380	HQLFRGFSFVATGLM	+
RSK2 (RPS6KA3)	P51812	S386	HQLFRGFSFVAITSD	+
S6	P62753	S235	IAKRRRLSSLRASTS	+
S6	P62753	S236	AKRRRLSSLRASTSK	+
S6	P62753	S240	RLSSLRASTSKSESS	+
S6	P62753	S244	LRASTSKSESSQK__	+
S6	P62753	S247	STSKSESSQK_____	+
Tau iso8	P10636-8	S214	GSRSRTPSLPTPPTR
Tau iso8	P10636-8	S262	NVKSKIGSTENLKHQ
Tau iso8	P10636-8	T212	TPGSRSRTPSLPTPP
CAD	P27708	S1859	PPRIHRASDPGLPAE	+

Protein Kinase Specificity

Matrix of observed frequency (%) of amino acids in aligned protein substrate phosphosites

Matrix Type:

Experimentally derived from alignment of 58 known protein substrate phosphosites and 62 peptides phosphorylated by recombinant p70S6K in vitro tested in-house by Kinexus.

Domain #:

Inhibitors

For further details on these inhibitors click on the Compound Name and enter it into DrugKiNET or click on the ID's

Based on in vitro and/or in vivo phosphorylation data

Compound Name	KD, Ki or IC50 (nM)	PubChem ID	ChEMBL ID	PubMed ID

CHEMBL1684800	IC50 = 1 nM	52938983	1684800	21353571
Staurosporine	Kd = 1.3 nM	5279		22037378
AT13148	IC50 = 8 nM
TTT-3002	IC50 < 8 nM
Ro-31-8220	IC50 = 15 nM	5083	6291	10998351
SB218078	IC50 < 25 nM	447446	289422	22037377
Gö6976	IC50 < 40 nM	3501	302449
Gö7874	IC50 < 40 nM	5327863
SB747651A	IC50 < 40 nM	11393719	188434
Sunitinib	Kd = 48 nM	5329102	535	22037378
Bisindolylmaleimide I	IC50 > 50 nM	2396	7463	22037377
K-252a; Nocardiopsis sp.	IC50 > 50 nM	3813	281948	22037377
GSK269962A	IC50 < 60 nM	16095342	220241
Staurosporine aglycone	IC50 < 60 nM	3035817	281948
Lestaurtinib	Kd = 69 nM	126565		22037378
A 443654	IC50 < 80 nM	10172943	379300
H-89	IC50 = 80 nM	449241	104264	10998351
PF-4708671	IC50 < 80 nM
AT7867	IC50 = 85 nM	11175137	428462	20423992
7-hydroxystaurosporine	IC50 > 100 nM	72271	1236539
AT9283	IC50 > 100 nM	24905142		19143567
PP242	IC50 = 100 nM	25243800
SureCN2579964	IC50 < 100 nM	290221	233000	22934575
CHEMBL1171647	IC50 = 110 nM	25061501	1171647	20481595
AST-487	Kd = 120 nM	11409972	574738	22037378
Gö6983	IC50 > 150 nM	3499	261491	22037377
JAK3 Inhibitor VI	IC50 > 150 nM	16760524		22037377
N-Benzoylstaurosporine	IC50 > 150 nM	56603681	608533	22037377
Ro-32-0432	IC50 > 150 nM	127757	26501	22037377
SU14813	Kd = 150 nM	10138259	1721885	22037378
Nintedanib	Kd = 190 nM	9809715	502835	22037378
CCT128930	IC50 < 200 nM	17751819		18345609
SureCN2505235	IC50 < 200 nM	23649240		22934575
Ruboxistaurin	Kd = 210 nM	153999	91829	22037378
Cdk1/2 Inhibitor III	IC50 > 250 nM	5330812	261720	22037377
PKCb Inhibitor	IC50 > 250 nM	6419755	366266	22037377
SU11652	IC50 > 250 nM	24906267	13485	22037377
Syk Inhibitor	IC50 > 250 nM	6419747	104279	22037377
KW2449	Kd = 310 nM	11427553	1908397	22037378
ALX-270-403-M001	IC50 = 500 nM			22037377
IDR E804	IC50 = 500 nM	6419764	1802727	22037377
CHEMBL482967	Ki = 540 nM	6420138	482967	20462263
Dovitinib	Kd = 570 nM	57336746		22037378
Amgen TBK 1 inhibitor (Compound II)	IC50 < 600 nM
GDC-0068	IC50 < 600 nM	24995523		22934575
GSK-3 Inhibitor IX	IC50 < 600 nM	5287844	409450
GSK429286	IC50 < 600 nM	11373846	375312
Syk Inhibitor IV	IC50 < 600 nM	10200390
Crizotinib	Kd = 640 nM	11626560	601719	22037378
Bosutinib	Kd = 660 nM	5328940	288441	22037378
Momelotinib	IC50 < 750 nM	25062766		19295546
BX795	IC50 < 800 nM	10077147	577784
SureCN3470757	IC50 < 800 nM	11588244	375236
BX517	IC50 > 900 nM	11161844	228654
Baricitinib	IC50 > 1 µM	44205240		20363976
BI-D1870	IC50 = 1 µM	25023738	573107
CHIR-98014	IC50 > 1 µM	9868037		12606497
CK7	Ki > 1 µM	447961		15027857
CP673451	IC50 > 1 µM	10158940		15705896
GSK-3 Inhibitor XIII	IC50 > 1 µM	6419766	359482	22037377
HA-1100	IC50 = 1 µM	3064778	1233300
Icotinib	IC50 > 1 µM	22024915		22112293
IPA-3	IC50 = 1 µM	521106	472940
Kinome_714	IC50 > 1 µM	46886323		20346655
MK5108	IC50 > 1 µM	24748204		20053775
Orantinib	IC50 = 1 µM	5329099	274654
PKR Inhibitor	IC50 > 1 µM	6490494	235641	22037377
PP1	IC50 = 1 µM	1400	306380
R406	IC50 = 1 µM	11984591
Silmitasertib	IC50 > 1 µM	24748573		21174434
SNS314	IC50 > 1 µM	16047143	514582	18678489
SureCN10063060	Ki > 1 µM	52936621		21391610
TG101209	IC50 > 1 µM	16722832		17541402
Wyeth PDK1 Inhibitor Compound 1	IC50 = 1 µM
WZ3146	Kd > 1 µM	44607360		20033049
WZ4002	Kd > 1 µM	44607530		20033049
Foretinib	Kd = 1.2 µM	42642645	1230609	22037378
Vandetanib	Kd = 1.6 µM	3081361	24828	22037378
Enzastaurin	Kd = 1.8 µM	176167	300138	22037378
GSK429286A	IC50 = 1.94 µM	11373846		17201405
FMK	IC50 < 2 µM	5737
PF-228	IC50 > 2 µM	11612883		17395594
TG101348	Kd = 2 µM	16722836	1287853	22037378
NVP-TAE684	Kd = 2.7 µM	16038120	509032	22037378
CHEMBL436137	IC50 = 2.71 µM	11719421	436137	16931012
Barasertib	Kd = 2.8 µM	16007391	215152	22037378
Linifanib	Kd = 2.8 µM	11485656	223360	22037378
JNK Inhibitor VIII	Ki = 3.4 µM	11624601	210618	16759099
SureCN4875304	IC50 > 3.5 µM	46871765		20472445
A674563	Kd = 3.6 µM	11314340	379218	22037378
Alvocidib	Kd = 3.7 µM	9910986	428690	22037378
BI-78D3	IC50 < 4 µM	2747117	508280
JNJ-28871063	IC50 > 4 µM	17747413		17975007
Princeton's TrkA inhibitor compound 20h	IC50 < 4 µM
Quercetagetin	IC50 < 4 µM	5281680	413552
Semaxinib	IC50 < 4 µM	5329098	276711
PHA-665752	Kd = 4.1 µM	10461815	450786	22037378
GW441756 hydrochloride	IC50 > 4.5 µM	16219400
Ruxolitinib	IC50 > 4.5 µM	25126798	1789941
Tofacitinib	IC50 > 4.5 µM	9926791	221959

Disease Linkage

General Disease Association:

Genetic disorders

Specific Diseases (Non-cancerous):

Tuberous sclerosis; Tuberous sclerosis complex

Comments:

Tuberous sclerosis is a rare genetic disease characterized by the growth of benign tumours (non-cancerous) in the brain and other organs. Symptoms are variable dependent upon location of tumour growth. Common symptoms include light-coloured patches of skin, areas of thickened skin, and tumour growth under the nails. This disease is inherited in an autosomal dominant manner. Known mutations in p70S6K are associated with a gain-of-function phenotype through the facilitation of phosphorylation by the upstream kinase PDPK1. These mutations are associated with tuberous sclerosis, potentially through the over-stimulation of cell growth and proliferation leading to aberrant proliferation of cells.

Gene Expression in Cancers:

TranscriptoNET (www.transcriptonet.ca) analysis with mRNA expression data retrieved from the National Center for Biotechnology Information's Gene Expression Omnibus (GEO) database, which was normalized against 60 abundantly and commonly found proteins, indicated altered expression for this protein kinase as shown here as the percent change from normal tissue controls (%CFC) as supported with the Student T-test in the following types of human cancers: Barrett's esophagus epithelial metaplasia (%CFC= -45, p<0.059); Cervical cancer (%CFC= +116, p<0.006); Clear cell renal cell carcinomas (cRCC) stage I (%CFC= +602, p<0.0001); Ovary adenocarcinomas (%CFC= +166, p<0.031); Pituitary adenomas (ACTH-secreting) (%CFC= -45); Prostate cancer - primary (%CFC= -87, p<0.0001); and Uterine leiomyomas from fibroids (%CFC= +66, p<0.035). The COSMIC website notes an up-regulated expression score for p70S6K in diverse human cancers of 766, which is 1.7-fold of the average score of 462 for the human protein kinases. The down-regulated expression score of 256 for this protein kinase in human cancers was 4.3-fold of the average score of 60 for the human protein kinases.

Mutagenesis Experiments:

Insertional mutagenesis studies in mice support a role for this protein kinase in mouse cancer oncogenesis.

Mutation Rate in All Cancers:

Percent mutation rates per 100 amino acids length in human cancers: 0.05 % in 25555 diverse cancer specimens. This rate is only -35 % lower than the average rate of 0.075 % calculated for human protein kinases in general.

Mutation Rate in Specific Cancers:

Highest percent mutation rates per 100 amino acids length in human cancers: 0.2 % in 1119 large intestine cancers tested; 0.13 % in 1942 lung cancers tested.

Frequency of Mutated Sites:

None > 4 in 20,718 cancer specimens

Comments:

Only 2 deletions, 1 insertion, and no complex mutations are noted on the COSMIC website.

COSMIC Entry:

RPS6KB1

OMIM Entry:

608938

Nomenclature

Short Name:

Full Name:

Alias:

Classification

Type:

Group:

Family:

SubFamily:

Specific Links

General Links

Structure

Mol. Mass (Da):

# Amino Acids:

# mRNA Isoforms:

mRNA Isoforms:

4D Structure:

1D Structure:

3D Image (rendered using PV Viewer):

PDB ID

Subfamily Alignment

Domain Distribution:

Kinexus Products

hiddentext

Post-translation Modifications

Acetylated:

Serine phosphorylated:

Threonine phosphorylated:

Tyrosine phosphorylated:

Distribution

Human Tissue Distribution

% Max Expression: Mean Expression: Number of Samples: Standard Deviation:

% Max Expression: Mean Expression: Number of Samples: Standard Deviation:

Evolution

Species Conservation

PhosphoNET % Identity: PhosphoNET % Similarity: Homologene %Identity:

PhosphoNET % Identity: PhosphoNET % Similarity: Homologene %Identity:

Binding Proteins

hiddentext

Regulation

Activation:

Inhibition:

Synthesis:

Degradation:

Known Upstream Kinases

Based on in vitro and/or in vivo phosphorylation data

Known Downstream Substrates

Based on in vitro and/or in vivo phosphorylation data

Protein Kinase Specificity

Matrix Type:

Domain #:

Inhibitors

Based on in vitro and/or in vivo phosphorylation data

Disease Linkage

General Disease Association:

Specific Diseases (Non-cancerous):

Comments:

Gene Expression in Cancers:

Mutagenesis Experiments:

Mutation Rate in All Cancers:

Mutation Rate in Specific Cancers:

Frequency of Mutated Sites:

Comments:

COSMIC Entry:

OMIM Entry:

% Max Expression:

Mean Expression:

Number of Samples:

Standard Deviation:

% Max Expression:

Mean Expression:

Number of Samples:

Standard Deviation:

PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity:

PhosphoNET % Identity:
PhosphoNET % Similarity:
Homologene %
Identity: